Actr8 ARP8 actin-related protein 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Actr8provided by MGI
Official Full Name: ARP8 actin-related protein 8provided by MGI
Primary source: MGI:MGI:1860775
See related: Ensembl:ENSMUSG00000015971
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARP8; 5730542K05Rik
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.1), CNS E14 (RPKM 10.1) and 28 other tissues See more
Orthologs: human all

Genomic context

Location:: 14; 14 B

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
108	current	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (29978337..29995452)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	14	NC_000080.5 (30791523..30806407)

Chromosome 14 - NC_000080.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Pathways from BioSystems

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DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
DNA Damage Recognition in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Deubiquitination, organism-specific biosystem (from REACTOME)
Deubiquitination, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
UCH proteinases, organism-specific biosystem (from REACTOME)
UCH proteinases, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Actr8 gene: The Actr8 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 301 organisms have orthologs with human gene Actr8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
ATP-dependent chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA recombination	IEA Inferred from Electronic Annotation more info
DNA repair	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cellular response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
chromatin remodeling	IEA Inferred from Electronic Annotation more info
double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of transcription, DNA-templated	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
Ino80 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
Ino80 complex	ISO Inferred from Sequence Orthology more info
centrosome	ISO Inferred from Sequence Orthology more info
chromosome	IEA Inferred from Electronic Annotation more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-related protein 8

Names: ARP8 actin-related protein 8 homolog; actin-related protein 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027493.3 → NP_081769.2 actin-related protein 8

See identical proteins and their annotated locations for NP_081769.2

Status: VALIDATED

Source sequence(s)

CT009536

Consensus CDS

CCDS26891.1

UniProtKB/Swiss-Prot

Q8R2S9

Related

ENSMUSP00000016115.4, ENSMUST00000016115.5

Conserved Domains (1) summary

cl17037
Location:167 → 618

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

NC_000080.6 Reference GRCm38.p6 C57BL/6J

Range

29978337..29995452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247897.1 → XP_030103757.1 actin-related protein 8 isoform X2
XM_006519309.4 → XP_006519372.2 actin-related protein 8 isoform X1

Conserved Domains (1) summary

cl17037
Location:167 → 576

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
XM_030247898.1 → XP_030103758.1 actin-related protein 8 isoform X3
XM_030247899.1 → XP_030103759.1 actin-related protein 8 isoform X4