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SLC22A13 solute carrier family 22 member 13 [ Homo sapiens (human) ]

Gene ID: 9390, updated on 2-Mar-2021

Summary

Official Symbol
SLC22A13provided by HGNC
Official Full Name
solute carrier family 22 member 13provided by HGNC
Primary source
HGNC:HGNC:8494
See related
Ensembl:ENSG00000172940 MIM:604047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT10; OCTL1; OCTL3; ORCTL3; ORCTL-3
Summary
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]
Expression
Restricted expression toward kidney (RPKM 6.8) See more
Orthologs
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Genomic context

See SLC22A13 in Genome Data Viewer
Location:
3p22.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (38265812..38278757)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38307303..38320248)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928234 Neighboring gene MYD88 innate immune signal transduction adaptor Neighboring gene oxidative stress responsive kinase 1 Neighboring gene cell division cycle 42 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5010 Neighboring gene solute carrier family 22 member 14 Neighboring gene RNA, U6 small nuclear 235, pseudogene Neighboring gene DLEC1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nicotinate transmembrane transporter activity EXP
Inferred from Experiment
more info
PubMed 
nicotinate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 22 member 13
Names
organic cationic transporter-like 3
organic-cation transporter like 3
solute carrier family 22 (organic anion transporter), member 13
solute carrier family 22 (organic anion/urate transporter), member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004256.4NP_004247.2  solute carrier family 22 member 13

    See identical proteins and their annotated locations for NP_004247.2

    Status: REVIEWED

    Source sequence(s)
    AB010438, AK315301, AP006193, DA629311
    Consensus CDS
    CCDS2676.1
    UniProtKB/Swiss-Prot
    Q9Y226
    Related
    ENSP00000310241.3, ENST00000311856.9
    Conserved Domains (2) summary
    cd06174
    Location:139500
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:12510
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    38265812..38278757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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