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Glrx glutaredoxin [ Mus musculus (house mouse) ]

Gene ID: 93692, updated on 17-Mar-2024

Summary

Official Symbol
Glrxprovided by MGI
Official Full Name
glutaredoxinprovided by MGI
Primary source
MGI:MGI:2135625
See related
Ensembl:ENSMUSG00000021591 AllianceGenome:MGI:2135625
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grx1; Glrx1; TTase; D13Wsu156e
Summary
Predicted to enable glutathione disulfide oxidoreductase activity and protein N-terminus binding activity. Predicted to be involved in several processes, including cellular response to estradiol stimulus; positive regulation of transport; and regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; and nervous system. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 132.0), placenta adult (RPKM 90.4) and 25 other tissues See more
Orthologs
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Genomic context

See Glrx in Genome Data Viewer
Location:
13 C1; 13 40.95 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (75988004..75998270)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75839885..75850151)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene elongation factor for RNA polymerase II 2 Neighboring gene predicted gene, 23127 Neighboring gene STARR-seq mESC enhancer starr_35046 Neighboring gene STARR-seq mESC enhancer starr_35047 Neighboring gene STARR-seq mESC enhancer starr_35048 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:75935293-75935499 Neighboring gene STARR-positive B cell enhancer ABC_E4080 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene STARR-seq mESC enhancer starr_35051 Neighboring gene Rho-related BTB domain containing 3 Neighboring gene predicted gene, 24163 Neighboring gene WD repeat domain 77 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione disulfide oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione disulfide oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-disulfide reductase (glutathione) activity TAS
Traceable Author Statement
more info
PubMed 
enables sodium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutaredoxin-1
Names
TTase-1
glutaredoxin (thioltransferase)
glutaredoxin 1 (thioltransferase)
thioltransferase-1
NP_001347080.1
NP_444338.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360151.1NP_001347080.1  glutaredoxin-1

    Status: VALIDATED

    Source sequence(s)
    AC158356, CT025556
    Consensus CDS
    CCDS26651.1
    UniProtKB/Swiss-Prot
    Q9QUH0
    UniProtKB/TrEMBL
    Q3U6L3, Q9D6F8
    Conserved Domains (1) summary
    TIGR02180
    Location:1599
    GRX_euk; Glutaredoxin
  2. NM_053108.4NP_444338.2  glutaredoxin-1

    See identical proteins and their annotated locations for NP_444338.2

    Status: VALIDATED

    Source sequence(s)
    AK153086, BY272278, CO796000
    Consensus CDS
    CCDS26651.1
    UniProtKB/Swiss-Prot
    Q9QUH0
    UniProtKB/TrEMBL
    Q3U6L3, Q9D6F8
    Related
    ENSMUSP00000022082.8, ENSMUST00000022082.8
    Conserved Domains (1) summary
    TIGR02180
    Location:1599
    GRX_euk; Glutaredoxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    75988004..75998270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)