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TCEAL1 transcription elongation factor A like 1 [ Homo sapiens (human) ]

Gene ID: 9338, updated on 12-Oct-2019

Summary

Official Symbol
TCEAL1provided by HGNC
Official Full Name
transcription elongation factor A like 1provided by HGNC
Primary source
HGNC:HGNC:11616
See related
Ensembl:ENSG00000172465 MIM:300237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p21; SIIR; WEX9; pp21
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 48.1), endometrium (RPKM 41.3) and 24 other tissues See more
Orthologs

Genomic context

See TCEAL1 in Genome Data Viewer
Location:
Xq22.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103628716..103630953)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102883648..102885881)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transcription elongation factor A like 4 Neighboring gene uncharacterized LOC105373302 Neighboring gene transcription elongation factor A like 3 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene transmembrane protein 188 pseudogene Neighboring gene mortality factor 4 like 2 Neighboring gene MORF4L2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TCEAL3

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
WW domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor A protein-like 1
Names
TCEA-like protein 1
nuclear phosphoprotein p21/SIIR
transcription elongation factor A (SII)-like 1
transcription elongation factor S-II protein-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006639.2NP_001006640.1  transcription elongation factor A protein-like 1

    See identical proteins and their annotated locations for NP_001006640.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same isoform.
    Source sequence(s)
    BC000809, BM784458
    Consensus CDS
    CCDS35358.1
    UniProtKB/Swiss-Prot
    Q15170
    Related
    ENSP00000361707.3, ENST00000372624.3
    Conserved Domains (1) summary
    pfam04538
    Location:80158
    BEX; Brain expressed X-linked like family
  2. NM_001006640.2NP_001006641.1  transcription elongation factor A protein-like 1

    See identical proteins and their annotated locations for NP_001006641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 3 encode the same isoform.
    Source sequence(s)
    AL049610, BC000809, BU602495, BX092470
    Consensus CDS
    CCDS35358.1
    UniProtKB/Swiss-Prot
    Q15170
    Related
    ENSP00000361709.3, ENST00000372626.7
    Conserved Domains (1) summary
    pfam04538
    Location:80158
    BEX; Brain expressed X-linked like family
  3. NM_004780.3NP_004771.2  transcription elongation factor A protein-like 1

    See identical proteins and their annotated locations for NP_004771.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the complete protein. Variants 1 through 3 encode the same isoform.
    Source sequence(s)
    BC000809, CB053221, CF454849
    Consensus CDS
    CCDS35358.1
    UniProtKB/Swiss-Prot
    Q15170
    Related
    ENSP00000361708.3, ENST00000372625.8
    Conserved Domains (1) summary
    pfam04538
    Location:80158
    BEX; Brain expressed X-linked like family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103628716..103630953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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