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TCEAL3 transcription elongation factor A like 3 [ Homo sapiens (human) ]

Gene ID: 85012, updated on 1-Jun-2020

Summary

Official Symbol
TCEAL3provided by HGNC
Official Full Name
transcription elongation factor A like 3provided by HGNC
Primary source
HGNC:HGNC:28247
See related
Ensembl:ENSG00000196507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX8
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 39.3), brain (RPKM 35.9) and 25 other tissues See more
Orthologs

Genomic context

See TCEAL3 in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103607906..103609927)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102862834..102864855)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene transcription elongation factor A like 4 Neighboring gene uncharacterized LOC105373302 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Potential readthrough

Included gene: TCEAL1

Homology

Clone Names

  • MGC15737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription elongation factor A protein-like 3
Names
TCEA-like protein 3
transcription elongation factor A (SII)-like 3
transcription elongation factor S-II protein-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006933.1NP_001006934.1  transcription elongation factor A protein-like 3

    See identical proteins and their annotated locations for NP_001006934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AF163263, BC008703
    Consensus CDS
    CCDS14511.1
    UniProtKB/Swiss-Prot
    Q969E4
    Related
    ENSP00000243286.3, ENST00000243286.7
    Conserved Domains (2) summary
    pfam04538
    Location:81173
    BEX; Brain expressed X-linked like family
    cl27511
    Location:2104
    Na_Ca_ex; Sodium/calcium exchanger protein
  2. NM_032926.3NP_116315.1  transcription elongation factor A protein-like 3

    See identical proteins and their annotated locations for NP_116315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008703
    Consensus CDS
    CCDS14511.1
    UniProtKB/Swiss-Prot
    Q969E4
    Related
    ENSP00000361710.5, ENST00000372627.10
    Conserved Domains (2) summary
    pfam04538
    Location:81173
    BEX; Brain expressed X-linked like family
    cl27511
    Location:2104
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103607906..103609927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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