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GPR55 G protein-coupled receptor 55 [ Homo sapiens (human) ]

Gene ID: 9290, updated on 5-Aug-2018

Summary

Official Symbol
GPR55provided by HGNC
Official Full Name
G protein-coupled receptor 55provided by HGNC
Primary source
HGNC:HGNC:4511
See related
Ensembl:ENSG00000135898 MIM:604107; Vega:OTTHUMG00000133224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPIR1
Summary
This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction pathways. [provided by RefSeq, Aug 2013]
Expression
Biased expression in testis (RPKM 2.7), spleen (RPKM 2.0) and 13 other tissues See more
Orthologs

Genomic context

See GPR55 in Genome Data Viewer
Location:
2q37.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (230907318..230961270, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231772043..231789953, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene integral membrane protein 2C Neighboring gene uncharacterized LOC151484 Neighboring gene COX20, cytochrome c oxidase assembly factor pseudogene 2 Neighboring gene SPATA3 antisense RNA 1 (head to head) Neighboring gene spermatogenesis associated 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of G protein-coupled receptor 55 (GPR55) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
cannabinoid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cannabinoid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
G-protein coupled receptor 55

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050956.1 RefSeqGene

    Range
    41002..58900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005683.3NP_005674.2  G-protein coupled receptor 55

    See identical proteins and their annotated locations for NP_005674.2

    Status: REVIEWED

    Source sequence(s)
    AC012507, BC032694
    Consensus CDS
    CCDS2480.1
    UniProtKB/Swiss-Prot
    Q9Y2T6
    UniProtKB/TrEMBL
    A8K858
    Related
    ENSP00000375894.1, ENST00000392040.5
    Conserved Domains (1) summary
    cd15165
    Location:21299
    7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    230907318..230961270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512175.3XP_011510477.1  G-protein coupled receptor 55 isoform X1

    See identical proteins and their annotated locations for XP_011510477.1

    UniProtKB/Swiss-Prot
    Q9Y2T6
    UniProtKB/TrEMBL
    A8K858
    Related
    ENSP00000375893.2, OTTHUMP00000204443, ENST00000392039.2
    Conserved Domains (1) summary
    cd15165
    Location:21299
    7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_011512176.2XP_011510478.1  G-protein coupled receptor 55 isoform X1

    See identical proteins and their annotated locations for XP_011510478.1

    UniProtKB/Swiss-Prot
    Q9Y2T6
    UniProtKB/TrEMBL
    A8K858
    Conserved Domains (1) summary
    cd15165
    Location:21299
    7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_005246952.4XP_005247009.1  G-protein coupled receptor 55 isoform X1

    See identical proteins and their annotated locations for XP_005247009.1

    UniProtKB/Swiss-Prot
    Q9Y2T6
    UniProtKB/TrEMBL
    A8K858
    Conserved Domains (1) summary
    cd15165
    Location:21299
    7tmA_GPR55-like; G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
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