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NPIPA1 nuclear pore complex interacting protein family member A1 [ Homo sapiens (human) ]

Gene ID: 9284, updated on 18-Sep-2021

Summary

Official Symbol
NPIPA1provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member A1provided by HGNC
Primary source
HGNC:HGNC:7909
See related
Ensembl:ENSG00000183426 MIM:606406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIP; NPIPA; morpheus
Expression
Ubiquitous expression in skin (RPKM 56.3), ovary (RPKM 53.3) and 25 other tissues See more
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Genomic context

See NPIPA1 in Genome Data Viewer
Location:
16p13.11
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (14937443..14952056)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15031300..15045913)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene PKD1P3-NPIPA1 readthrough Neighboring gene uncharacterized LOC100288162 Neighboring gene microRNA 6511a-1 Neighboring gene polycystin 1, transient receptor potential channel interacting pseudogene 3 Neighboring gene microRNA 6770-1 Neighboring gene pyridoxal dependent decarboxylase domain containing 1 Neighboring gene KIAA2013 pseudogene Neighboring gene microRNA 1972-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nuclear pore complex interacting protein (NPIP) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
Knockdown of nuclear pore complex interacting protein (NPIP) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough PKD1P3-NPIPA1

Readthrough gene: PKD1P3-NPIPA1, Included gene: PKD1P3

Clone Names

  • FLJ42525, FLJ44848

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nuclear pore complex-interacting protein family member A1
Names
nuclear pore complex-interacting protein A type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006985.4NP_008916.2  nuclear pore complex-interacting protein family member A1

    See identical proteins and their annotated locations for NP_008916.2

    Status: VALIDATED

    Source sequence(s)
    AC138932, KF175225
    Consensus CDS
    CCDS10557.1
    UniProtKB/Swiss-Prot
    Q9UND3
    Related
    ENSP00000331843.6, ENST00000328085.10
    Conserved Domains (1) summary
    pfam06409
    Location:22287
    NPIP; Nuclear pore complex interacting protein (NPIP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    14937443..14952056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    781135..791387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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