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TMEM169 transmembrane protein 169 [ Homo sapiens (human) ]

Gene ID: 92691, updated on 23-Nov-2021

Summary

Official Symbol
TMEM169provided by HGNC
Official Full Name
transmembrane protein 169provided by HGNC
Primary source
HGNC:HGNC:25130
See related
Ensembl:ENSG00000163449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 3.2), thyroid (RPKM 1.2) and 12 other tissues See more
Orthologs
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Genomic context

See TMEM169 in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (216081919..216102783)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216946642..216967506)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373870 Neighboring gene melanoregulin Neighboring gene peroxisomal trans-2-enoyl-CoA reductase Neighboring gene Sharpr-MPRA regulatory regions 7837 and 8351 Neighboring gene X-ray repair cross complementing 5 Neighboring gene DNA polymerase eta pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34263, DKFZp781L2456

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142310.2NP_001135782.1  transmembrane protein 169

    See identical proteins and their annotated locations for NP_001135782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
    Source sequence(s)
    AK091582, AK172731, AW291087, DA718294
    Consensus CDS
    CCDS2401.1
    UniProtKB/Swiss-Prot
    Q96HH4
    UniProtKB/TrEMBL
    A0A024R430
    Related
    ENSP00000412524.1, ENST00000454545.5
    Conserved Domains (1) summary
    pfam15052
    Location:147276
    TMEM169; TMEM169 protein family
  2. NM_001142311.2NP_001135783.1  transmembrane protein 169

    See identical proteins and their annotated locations for NP_001135783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AK091582, AW291087, BC008604
    Consensus CDS
    CCDS2401.1
    UniProtKB/Swiss-Prot
    Q96HH4
    UniProtKB/TrEMBL
    A0A024R430
    Related
    ENSP00000401305.2, ENST00000437356.7
    Conserved Domains (1) summary
    pfam15052
    Location:147276
    TMEM169; TMEM169 protein family
  3. NM_001142312.2NP_001135784.1  transmembrane protein 169

    See identical proteins and their annotated locations for NP_001135784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AK091582, AK172731, AW291087, DA392602
    Consensus CDS
    CCDS2401.1
    UniProtKB/Swiss-Prot
    Q96HH4
    UniProtKB/TrEMBL
    A0A024R430
    Conserved Domains (1) summary
    pfam15052
    Location:147276
    TMEM169; TMEM169 protein family
  4. NM_138390.4NP_612399.1  transmembrane protein 169

    See identical proteins and their annotated locations for NP_612399.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AK091582, AK172731, AW291087
    Consensus CDS
    CCDS2401.1
    UniProtKB/Swiss-Prot
    Q96HH4
    UniProtKB/TrEMBL
    A0A024R430
    Related
    ENSP00000295658.4, ENST00000295658.8
    Conserved Domains (1) summary
    pfam15052
    Location:147276
    TMEM169; TMEM169 protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    216081919..216102783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712851.1XP_006712914.1  transmembrane protein 169 isoform X1

    See identical proteins and their annotated locations for XP_006712914.1

    UniProtKB/Swiss-Prot
    Q96HH4
    UniProtKB/TrEMBL
    A0A024R430
    Related
    ENSP00000384100.2, ENST00000406027.2
    Conserved Domains (1) summary
    pfam15052
    Location:147276
    TMEM169; TMEM169 protein family
  2. XM_011512173.2XP_011510475.1  transmembrane protein 169 isoform X1

    See identical proteins and their annotated locations for XP_011510475.1

    UniProtKB/Swiss-Prot
    Q96HH4
    UniProtKB/TrEMBL
    A0A024R430
    Conserved Domains (1) summary
    pfam15052
    Location:147276
    TMEM169; TMEM169 protein family
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