U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NUMBL NUMB like endocytic adaptor protein [ Homo sapiens (human) ]

Gene ID: 9253, updated on 27-Nov-2024

Summary

Official Symbol
NUMBLprovided by HGNC
Official Full Name
NUMB like endocytic adaptor proteinprovided by HGNC
Primary source
HGNC:HGNC:8061
See related
Ensembl:ENSG00000105245 MIM:604018; AllianceGenome:HGNC:8061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBL; CAG3A; CTG3a; NUMBR; NUMB-R; TNRC23; NUMBLIKE
Summary
Involved in cytokine-mediated signaling pathway. Predicted to be active in cytoplasm and glutamatergic synapse. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in brain (RPKM 8.6), endometrium (RPKM 7.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NUMBL in Genome Data Viewer
Location:
19q13.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (40665905..40690651, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43486573..43511317, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41171810..41196556, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10635 Neighboring gene SH3KBP1 binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 6117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14657 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41108540-41109063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10637 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10639 Neighboring gene Sharpr-MPRA regulatory region 12022 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14658 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41119811-41120358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14659 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41128498-41129138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41136805-41137395 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:41142798-41142919 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:41153389-41154370 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10641 Neighboring gene Sharpr-MPRA regulatory region 4590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41194847-41195786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41196725-41197662 Neighboring gene coenzyme Q8B Neighboring gene RNA, U6 small nuclear 195, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:41224841-41225542 Neighboring gene inositol-trisphosphate 3-kinase C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of numb homolog (Drosophila)-like (NUMBL) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lateral ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuroblast division in subventricular zone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neurogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
numb-like protein
Names
numb homolog-like
numb-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289979.2NP_001276908.1  numb-like protein isoform b

    See identical proteins and their annotated locations for NP_001276908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC010412, BC144583, HY111715
    Consensus CDS
    CCDS77298.1
    UniProtKB/TrEMBL
    A0A0C4DGH3, B7Z5W0
    Related
    ENSP00000472400.1, ENST00000598779.5
    Conserved Domains (3) summary
    cd01268
    Location:23157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:246330
    NumbF; NUMB domain
    cl25764
    Location:348516
    PAT1; Topoisomerase II-associated protein PAT1
  2. NM_001289980.2NP_001276909.1  numb-like protein isoform b

    See identical proteins and their annotated locations for NP_001276909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) ) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC010412, AK299484, DC374917
    Consensus CDS
    CCDS77298.1
    UniProtKB/TrEMBL
    A0A0C4DGH3, B7Z5W0
    Related
    ENSP00000442759.1, ENST00000540131.5
    Conserved Domains (3) summary
    cd01268
    Location:23157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:246330
    NumbF; NUMB domain
    cl25764
    Location:348516
    PAT1; Topoisomerase II-associated protein PAT1
  3. NM_004756.5NP_004747.1  numb-like protein isoform a

    See identical proteins and their annotated locations for NP_004747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC010412, AK289398
    Consensus CDS
    CCDS12561.1
    UniProtKB/Swiss-Prot
    Q7Z4J9, Q9Y6R0
    UniProtKB/TrEMBL
    A8K033
    Related
    ENSP00000252891.3, ENST00000252891.8
    Conserved Domains (2) summary
    cd01268
    Location:64198
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:287371
    NumbF; NUMB domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    40665905..40690651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43486573..43511317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)