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DHRS3 dehydrogenase/reductase 3 [ Homo sapiens (human) ]

Gene ID: 9249, updated on 11-Sep-2019

Summary

Official Symbol
DHRS3provided by HGNC
Official Full Name
dehydrogenase/reductase 3provided by HGNC
Primary source
HGNC:HGNC:17693
See related
Ensembl:ENSG00000162496 MIM:612830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1
Summary
Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
Expression
Ubiquitous expression in liver (RPKM 41.2), fat (RPKM 39.1) and 25 other tissues See more
Orthologs

Genomic context

See DHRS3 in Genome Data Viewer
Location:
1p36.21
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (12567910..12618210, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12627939..12677820, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2766 Neighboring gene Sharpr-MPRA regulatory region 4366 Neighboring gene RNA, U6atac small nuclear 18, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5682 Neighboring gene microRNA 6730 Neighboring gene arylacetamide deacetylase like 4 Neighboring gene arylacetamide deacetylase like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP-retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
retinol dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
negative regulation of retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
regulation of retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process TAS
Traceable Author Statement
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
photoreceptor outer segment membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short-chain dehydrogenase/reductase 3
Names
dehydrogenase/reductase (SDR family) member 3
dehydrogenase/reductase member 3
retinal short-chain dehydrogenase/reductase 1
retinol dehydrogenase 17
short chain dehydrogenase/reductase family 16C member 1
short-chain dehydrogenase/reductase 1
NP_001306154.1
NP_001311299.1
NP_004744.2
XP_006711099.1
XP_016858298.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319225.2NP_001306154.1  short-chain dehydrogenase/reductase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC254633, AK225057
    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  2. NM_001324370.2NP_001311299.1  short-chain dehydrogenase/reductase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC254633
    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  3. NM_004753.7NP_004744.2  short-chain dehydrogenase/reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_004744.2

    Status: VALIDATED

    Source sequence(s)
    AC254633, BX648476
    Consensus CDS
    CCDS146.1
    UniProtKB/Swiss-Prot
    O75911
    Related
    ENSP00000480439.1, ENST00000616661.5
    Conserved Domains (1) summary
    cd05339
    Location:53281
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    12567910..12618210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711036.2XP_006711099.1  short-chain dehydrogenase/reductase 3 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:53117
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_017002809.1XP_016858298.1  short-chain dehydrogenase/reductase 3 isoform X1

    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
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