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DHRS3 dehydrogenase/reductase 3 [ Homo sapiens (human) ]

Gene ID: 9249, updated on 23-Nov-2023

Summary

Official Symbol
DHRS3provided by HGNC
Official Full Name
dehydrogenase/reductase 3provided by HGNC
Primary source
HGNC:HGNC:17693
See related
Ensembl:ENSG00000162496 MIM:612830; AllianceGenome:HGNC:17693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1; CNALPTC1
Summary
Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane and photoreceptor outer segment membrane. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 41.2), fat (RPKM 39.1) and 25 other tissues See more
Orthologs
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Genomic context

See DHRS3 in Genome Data Viewer
Location:
1p36.21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12567910..12618210, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12112042..12164110, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12627939..12678216, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12568463-12568964 Neighboring gene small nucleolar RNA, H/ACA box 59A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12600378-12601026 Neighboring gene Sharpr-MPRA regulatory region 4366 Neighboring gene long intergenic non-protein coding RNA 2766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12608056-12608563 Neighboring gene Sharpr-MPRA regulatory region 1458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12612066-12613020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12613021-12613973 Neighboring gene Sharpr-MPRA regulatory region 5682 Neighboring gene RNA, U6atac small nuclear 18, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12652795-12653294 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12663043-12663228 Neighboring gene Sharpr-MPRA regulatory region 11784 Neighboring gene microRNA 6730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12677840-12678472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12678473-12679104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12679105-12679736 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12679972-12680223 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12736484-12736819 Neighboring gene arylacetamide deacetylase like 4 Neighboring gene uncharacterized LOC124903846 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:12763477-12764676

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD-retinol dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NADP-retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
enables electron transfer activity TAS
Traceable Author Statement
more info
PubMed 
enables nucleotide binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in bone morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of retinoic acid receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retinoid metabolic process TAS
Traceable Author Statement
more info
 
involved_in retinol metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in photoreceptor outer segment membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short-chain dehydrogenase/reductase 3
Names
copy number amplified long noncoding RNA in papillary thyroid cancer 1
dehydrogenase/reductase (SDR family) member 3
dehydrogenase/reductase member 3
retinal short-chain dehydrogenase/reductase 1
retinol dehydrogenase 17
short chain dehydrogenase/reductase family 16C member 1
short-chain dehydrogenase/reductase 1
NP_001306154.1
NP_001311299.1
NP_004744.2
XP_006711099.1
XP_016858298.1
XP_047290362.1
XP_054195601.1
XP_054195602.1
XP_054195603.1
XP_054195604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319225.2NP_001306154.1  short-chain dehydrogenase/reductase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC254633, AK225057
    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  2. NM_001324370.2NP_001311299.1  short-chain dehydrogenase/reductase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC254633
    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  3. NM_004753.7NP_004744.2  short-chain dehydrogenase/reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_004744.2

    Status: VALIDATED

    Source sequence(s)
    AC254633, BX648476
    Consensus CDS
    CCDS146.1
    UniProtKB/Swiss-Prot
    B2R7F3, O75911, Q5VUY3, Q6UY38, Q9BUC8
    UniProtKB/TrEMBL
    Q53HI7
    Related
    ENSP00000480439.1, ENST00000616661.5
    Conserved Domains (1) summary
    cd05339
    Location:53281
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    12567910..12618210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711036.3XP_006711099.1  short-chain dehydrogenase/reductase 3 isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:53117
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_047434406.1XP_047290362.1  short-chain dehydrogenase/reductase 3 isoform X1

  3. XM_017002809.2XP_016858298.1  short-chain dehydrogenase/reductase 3 isoform X2

    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    12112042..12164110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339626.1XP_054195601.1  short-chain dehydrogenase/reductase 3 isoform X4

    UniProtKB/Swiss-Prot
    B2R7F3, O75911, Q5VUY3, Q6UY38, Q9BUC8
    UniProtKB/TrEMBL
    Q53HI7
  2. XM_054339629.1XP_054195604.1  short-chain dehydrogenase/reductase 3 isoform X3

  3. XM_054339627.1XP_054195602.1  short-chain dehydrogenase/reductase 3 isoform X1

  4. XM_054339628.1XP_054195603.1  short-chain dehydrogenase/reductase 3 isoform X2