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Dhrs3 dehydrogenase/reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 20148, updated on 8-Feb-2024

Summary

Official Symbol
Dhrs3provided by MGI
Official Full Name
dehydrogenase/reductase 3provided by MGI
Primary source
MGI:MGI:1315215
See related
Ensembl:ENSMUSG00000066026 AllianceGenome:MGI:1315215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsdr1; retSDR1
Summary
Enables NAD-retinol dehydrogenase activity. Acts upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 53.4), bladder adult (RPKM 42.8) and 22 other tissues See more
Orthologs
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Genomic context

See Dhrs3 in Genome Data Viewer
Location:
4 E1; 4 78.14 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144618712..144654214)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (144892534..144928209)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11990 Neighboring gene STARR-seq mESC enhancer starr_11991 Neighboring gene peroxiredoxin 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_11992 Neighboring gene predicted gene, 46890 Neighboring gene STARR-seq mESC enhancer starr_11993 Neighboring gene STARR-positive B cell enhancer ABC_E8006 Neighboring gene STARR-positive B cell enhancer ABC_E10275 Neighboring gene vacuolar protein sorting 13D Neighboring gene predicted gene, 42344 Neighboring gene predicted gene, 36317

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD-retinol dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD-retinol dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables NADP-retinol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
short-chain dehydrogenase/reductase 3
Names
dehydrogenase/reductase (SDR family) member 3
retinal short-chain dehydrogenase/reductase 1
NP_001165895.1
NP_001344203.1
NP_001344204.2
NP_001344205.2
NP_001344206.1
NP_001411778.1
NP_001411779.1
NP_001411780.1
NP_001411781.1
NP_035433.1
XP_006538744.1
XP_030109228.1
XP_036019818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172424.3NP_001165895.1  short-chain dehydrogenase/reductase 3 isoform 2

    See identical proteins and their annotated locations for NP_001165895.1

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Consensus CDS
    CCDS51368.1
    UniProtKB/TrEMBL
    G5E8W9
    Related
    ENSMUSP00000126154.2, ENSMUST00000171001.8
    Conserved Domains (1) summary
    cd05339
    Location:27255
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  2. NM_001357274.2NP_001344203.1  short-chain dehydrogenase/reductase 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Consensus CDS
    CCDS51368.1
    UniProtKB/TrEMBL
    G5E8W9
    Conserved Domains (1) summary
    cd05339
    Location:27255
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  3. NM_001357275.2NP_001344204.2  short-chain dehydrogenase/reductase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
  4. NM_001357276.2NP_001344205.2  short-chain dehydrogenase/reductase 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
  5. NM_001357277.2NP_001344206.1  short-chain dehydrogenase/reductase 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Conserved Domains (1) summary
    cd05339
    Location:1196
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  6. NM_001424849.1NP_001411778.1  short-chain dehydrogenase/reductase 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
  7. NM_001424850.1NP_001411779.1  short-chain dehydrogenase/reductase 3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
  8. NM_001424851.1NP_001411780.1  short-chain dehydrogenase/reductase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
  9. NM_001424852.1NP_001411781.1  short-chain dehydrogenase/reductase 3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
  10. NM_011303.8NP_035433.1  short-chain dehydrogenase/reductase 3 isoform 1

    See identical proteins and their annotated locations for NP_035433.1

    Status: VALIDATED

    Source sequence(s)
    AL606909, AL626773
    Consensus CDS
    CCDS18912.1
    UniProtKB/Swiss-Prot
    O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6
    Related
    ENSMUSP00000122552.2, ENSMUST00000154208.8
    Conserved Domains (2) summary
    cd05339
    Location:53281
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    PRK09072
    Location:35288
    PRK09072; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    144618712..144654214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253368.2XP_030109228.1  short-chain dehydrogenase/reductase 3 isoform X2

    Conserved Domains (1) summary
    cd05339
    Location:48216
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  2. XM_006538681.5XP_006538744.1  short-chain dehydrogenase/reductase 3 isoform X2

    See identical proteins and their annotated locations for XP_006538744.1

    Conserved Domains (1) summary
    cd05339
    Location:48216
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
  3. XM_036163925.1XP_036019818.1  short-chain dehydrogenase/reductase 3 isoform X1

    Conserved Domains (1) summary
    cd05339
    Location:53233
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs