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UBE2L6 ubiquitin conjugating enzyme E2 L6 [ Homo sapiens (human) ]

Gene ID: 9246, updated on 21-Jan-2020

Summary

Official Symbol
UBE2L6provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 L6provided by HGNC
Primary source
HGNC:HGNC:12490
See related
Ensembl:ENSG00000156587 MIM:603890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIG-B; UBCH8
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in spleen (RPKM 48.8), lymph node (RPKM 38.4) and 24 other tissues See more
Orthologs

Genomic context

See UBE2L6 in Genome Data Viewer
Location:
11q12.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (57551655..57568330, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57319128..57335803, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 605, pseudogene Neighboring gene translocase of inner mitochondrial membrane 10 Neighboring gene smoothelin like 1 Neighboring gene ribosomal protein S4X pseudogene 13 Neighboring gene serpin family G member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40331

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding EXP
Inferred from Experiment
more info
PubMed 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin/ISG15-conjugating enzyme E2 L6
Names
E2 ubiquitin-conjugating enzyme L6
retinoic acid induced gene B protein
ubiquitin carrier protein L6
ubiquitin conjugating enzyme E2L 6
ubiquitin-protein ligase L6
NP_004214.1
NP_937826.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004223.5NP_004214.1  ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1

    See identical proteins and their annotated locations for NP_004214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC032491, H17887
    Consensus CDS
    CCDS7960.1
    UniProtKB/Swiss-Prot
    O14933
    Related
    ENSP00000287156.4, ENST00000287156.9
    Conserved Domains (1) summary
    pfam00179
    Location:6144
    UQ_con; Ubiquitin-conjugating enzyme
  2. NM_198183.2NP_937826.1  ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 2

    See identical proteins and their annotated locations for NP_937826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, as compared to variant 1. The encoded isoform (2) is thus shorter when it is compared to isoform 1.
    Source sequence(s)
    AK093462, DA097307, H17887
    Consensus CDS
    CCDS7961.1
    UniProtKB/Swiss-Prot
    O14933
    Related
    ENSP00000341980.4, ENST00000340573.8
    Conserved Domains (1) summary
    pfam00179
    Location:178
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    57551655..57568330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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