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Ube2l6 ubiquitin-conjugating enzyme E2L 6 [ Mus musculus (house mouse) ]

Gene ID: 56791, updated on 1-Mar-2024

Summary

Official Symbol
Ube2l6provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2L 6provided by MGI
Primary source
MGI:MGI:1914500
See related
Ensembl:ENSMUSG00000027078 AllianceGenome:MGI:1914500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIG-B; UBCH8; Ubce8; Ubcm8; 2810489I21Rik
Summary
Enables ISG15 transferase activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in liver. Orthologous to human UBE2L6 (ubiquitin conjugating enzyme E2 L6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 183.6), liver E14.5 (RPKM 167.2) and 13 other tissues See more
Orthologs
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Genomic context

See Ube2l6 in Genome Data Viewer
Location:
2 D; 2 49.45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84629172..84640347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84798828..84810003)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade G, member 1 Neighboring gene STARR-seq mESC enhancer starr_05010 Neighboring gene predicted gene, 36596 Neighboring gene STARR-positive B cell enhancer ABC_E1592 Neighboring gene STARR-seq mESC enhancer starr_05011 Neighboring gene smoothelin-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E2628 Neighboring gene translocase of inner mitochondrial membrane 10

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ISG15 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ISG15 transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ISG15 transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ISG15-protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within modification-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin/ISG15-conjugating enzyme E2 L6
Names
E2 ubiquitin conjugating enzyme
E2 ubiquitin-conjugating enzyme L6
ubiquitin carrier protein L6
ubiquitin-conjugating enzyme 8
ubiquitin-protein ligase L6
NP_064333.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019949.2NP_064333.2  ubiquitin/ISG15-conjugating enzyme E2 L6

    See identical proteins and their annotated locations for NP_064333.2

    Status: VALIDATED

    Source sequence(s)
    AK152113, CJ300190
    Consensus CDS
    CCDS16194.2
    UniProtKB/Swiss-Prot
    Q3U8R0, Q922F1, Q9CQN0, Q9QZU9
    UniProtKB/TrEMBL
    Q4FJY2
    Related
    ENSMUSP00000099702.3, ENSMUST00000102642.9
    Conserved Domains (2) summary
    COG5078
    Location:1147
    COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    pfam00179
    Location:6144
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84629172..84640347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)