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CD7 CD7 molecule [ Homo sapiens (human) ]

Gene ID: 924, updated on 11-Sep-2019

Summary

Official Symbol
CD7provided by HGNC
Official Full Name
CD7 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1695
See related
Ensembl:ENSG00000173762 MIM:186820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GP40; TP41; Tp40; LEU-9
Summary
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 5.2), appendix (RPKM 4.1) and 12 other tissues See more
Orthologs

Genomic context

See CD7 in Genome Data Viewer
Location:
17q25.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82314865..82320829, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80272746..80275480, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CSNK1D-CD7 intergenic CAGE-defined low expression enhancer Neighboring gene uncharacterized LOC107985059 Neighboring gene secreted and transmembrane 1 Neighboring gene testis expressed 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD7 PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD7 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell activation TAS
Traceable Author Statement
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
T-cell antigen CD7
Names
CD7 antigen (p41)
T-cell leukemia antigen
T-cell surface antigen Leu-9
p41 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006137.7NP_006128.1  T-cell antigen CD7 precursor

    See identical proteins and their annotated locations for NP_006128.1

    Status: REVIEWED

    Source sequence(s)
    AC132872, BC009293, BI906419, BM917451
    Consensus CDS
    CCDS11807.1
    UniProtKB/Swiss-Prot
    P09564
    UniProtKB/TrEMBL
    Q29VG3
    Related
    ENSP00000312027.3, ENST00000312648.8
    Conserved Domains (1) summary
    pfam07686
    Location:31132
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82314865..82320829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025316.1XP_016880805.1  T-cell antigen CD7 isoform X1

    UniProtKB/TrEMBL
    J3QLC7
    Related
    ENSP00000463489.1, ENST00000583376.1
    Conserved Domains (2) summary
    smart00410
    Location:131
    IG_like; Immunoglobulin like
    cl11960
    Location:132
    Ig; Immunoglobulin domain
  2. XM_011523608.1XP_011521910.1  T-cell antigen CD7 isoform X1

    UniProtKB/TrEMBL
    J3QLC7
    Conserved Domains (2) summary
    smart00410
    Location:131
    IG_like; Immunoglobulin like
    cl11960
    Location:132
    Ig; Immunoglobulin domain

RNA

  1. XR_001752681.1 RNA Sequence

  2. XR_001752680.1 RNA Sequence

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