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IL32 interleukin 32 [ Homo sapiens (human) ]

Gene ID: 9235, updated on 3-Oct-2020

Summary

Official Symbol
IL32provided by HGNC
Official Full Name
interleukin 32provided by HGNC
Primary source
HGNC:HGNC:16830
See related
Ensembl:ENSG00000008517 MIM:606001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma
Summary
This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 122.1), spleen (RPKM 121.0) and 22 other tissues See more
Orthologs

Genomic context

See IL32 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3065403..3069530)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3115313..3119668)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128770 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene matrix metallopeptidase 25 Neighboring gene MMP25 antisense RNA 1 Neighboring gene RNA, U1 small nuclear 125, pseudogene Neighboring gene uncharacterized LOC107984896 Neighboring gene uncharacterized LOC105371058 Neighboring gene RNA, U1 small nuclear 22, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef IL-32-treated M2-macrophages inhibit the strong activation of p38, IKK alpha/beta, and TAK1 by HIV-1 Nef PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
interleukin-32
Names
interleukin-32 eta
interleukin-32 small
interleukin-32 theta
natural killer cell transcript 4
natural killer cells protein 4
tumor necrosis factor alpha-inducing factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029254.1 RefSeqGene

    Range
    5092..9508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012631.4NP_001012649.1  interleukin-32 isoform B

    See identical proteins and their annotated locations for NP_001012649.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (B), also referred to as IL-32beta.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS32377.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000432850.2, ENST00000528163.6
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32
  2. NM_001012632.3NP_001012650.1  interleukin-32 isoform B

    See identical proteins and their annotated locations for NP_001012650.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein, isoform B, also referred to as IL-32beta.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS32377.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000411958.3, ENST00000444393.7
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32
  3. NM_001012633.4NP_001012651.1  interleukin-32 isoform A

    See identical proteins and their annotated locations for NP_001012651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' UTR and contains an alternate intron within the last exon of the coding region, compared to variant 1. The encoded isoform (A), also referred to as IL-32alpha, is shorter compared to isoform B.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS32378.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000380096.3, ENST00000396887.7
    Conserved Domains (1) summary
    pfam15225
    Location:69107
    IL32; Interleukin 32
  4. NM_001012634.4NP_001012652.1  interleukin-32 isoform C

    See identical proteins and their annotated locations for NP_001012652.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and an alternate in-frame exon within the coding region, compared to variant 1, resulting in a shorter protein (isoform C).
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS45394.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000008180.9, ENST00000008180.13
    Conserved Domains (1) summary
    pfam15225
    Location:49144
    IL32; Interleukin 32
  5. NM_001012635.4NP_001012653.1  interleukin-32 isoform C

    See identical proteins and their annotated locations for NP_001012653.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon within the coding region, compared to variant 1, resulting in a shorter protein (isoform C).
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS45394.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000433747.1, ENST00000530890.5
    Conserved Domains (1) summary
    pfam15225
    Location:49144
    IL32; Interleukin 32
  6. NM_001012636.2NP_001012654.1  interleukin-32 isoform D

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks two alternate exons in the 5' UTR and an alternate in-frame exon within the coding region, compared to variant 1, resulting in a shorter protein (isoform D). Please note that isoform D is not the same as isoform delta, which is represented by AY495333.1.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS32379.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000371648.3, ENST00000382213.7
    Conserved Domains (1) summary
    pfam15225
    Location:60155
    IL32; Interleukin 32
  7. NM_001012718.4NP_001012736.1  interleukin-32 isoform B

    See identical proteins and their annotated locations for NP_001012736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate in-frame splice site in the 5' UTR compared to variant 1. Variants 1 and 8 encode the same protein, isoform B, also referred to as IL-32beta.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS32377.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000405063.3, ENST00000440815.7
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32
  8. NM_001308078.4NP_001295007.1  interleukin-32 isoform E precursor

    See identical proteins and their annotated locations for NP_001295007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has a shorter 5' UTR and contains an additional segment in the central coding region compared to variant 1. The encoded isoform (E) is longer than isoform B.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS76811.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000380099.2, ENST00000396890.6
    Conserved Domains (1) summary
    pfam15225
    Location:115210
    IL32; Interleukin 32
  9. NM_001369587.3NP_001356516.1  interleukin-32 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000448354.1, ENST00000548807.5
    Conserved Domains (1) summary
    pfam15225
    Location:115210
    IL32; Interleukin 32
  10. NM_001369588.3NP_001356517.1  interleukin-32 isoform E

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000431775.1, ENST00000534507.5
    Conserved Domains (1) summary
    pfam15225
    Location:115210
    IL32; Interleukin 32
  11. NM_001369589.3NP_001356518.1  interleukin-32 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000437020.1, ENST00000529550.5
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32
  12. NM_001369590.3NP_001356519.1  interleukin-32 isoform C

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000436937.1, ENST00000529699.5
    Conserved Domains (1) summary
    pfam15225
    Location:57144
    IL32; Interleukin 32
  13. NM_001369591.3NP_001356520.1  interleukin-32 isoform C

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Conserved Domains (1) summary
    pfam15225
    Location:49144
    IL32; Interleukin 32
  14. NM_001369592.3NP_001356521.1  interleukin-32 isoform C

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Conserved Domains (1) summary
    pfam15225
    Location:49144
    IL32; Interleukin 32
  15. NM_001369593.3NP_001356522.1  interleukin-32 isoform F

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000433177.1, ENST00000531965.5
    Conserved Domains (1) summary
    pfam15225
    Location:59154
    IL32; Interleukin 32
  16. NM_001369595.3NP_001356524.1  interleukin-32 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Conserved Domains (1) summary
    pfam15225
    Location:4987
    IL32; Interleukin 32
  17. NM_001369596.3NP_001356525.1  interleukin-32 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000450364.1, ENST00000526464.6
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32
  18. NM_001376923.1NP_001363852.1  interleukin-32 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC108134
    Related
    ENSP00000432218.2, ENST00000525643.6
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32
  19. NM_004221.7NP_004212.4  interleukin-32 isoform B

    See identical proteins and their annotated locations for NP_004212.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein, isoform B, also referred to as IL-32beta.
    Source sequence(s)
    AC108134
    Consensus CDS
    CCDS32377.1
    UniProtKB/Swiss-Prot
    P24001
    Related
    ENSP00000324742.5, ENST00000325568.9
    Conserved Domains (1) summary
    pfam15225
    Location:69164
    IL32; Interleukin 32

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3065403..3069530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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