U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DLGAP2 DLG associated protein 2 [ Homo sapiens (human) ]

Gene ID: 9228, updated on 1-Mar-2024

Summary

Official Symbol
DLGAP2provided by HGNC
Official Full Name
DLG associated protein 2provided by HGNC
Primary source
HGNC:HGNC:2906
See related
Ensembl:ENSG00000198010 MIM:605438; AllianceGenome:HGNC:2906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAP2; SAPAP2; C8orf68; ERICH1-AS1
Summary
The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]
Expression
Biased expression in brain (RPKM 4.0), testis (RPKM 1.4) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DLGAP2 in Genome Data Viewer
Location:
8p23.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (737628..1708476)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (529208..1487141)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (687628..1656642)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:647979-648498 Neighboring gene glutamate rich 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:670296-670830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:669760-670295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:678707-679211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:677860-678646 Neighboring gene uncharacterized LOC124902044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:728526-729090 Neighboring gene uncharacterized LOC401442 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:736241-736398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:743529-744064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:790357-791126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:811009-811508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:810507-811008 Neighboring gene uncharacterized LOC105377777 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:840949-841688 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:841689-842428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:851295-851953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:851954-852611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:855381-855880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:864299-864799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:864873-865374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:883096-883666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:888712-889264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:888158-888711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:890486-890986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:899165-900128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:912422-912922 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:914952-916151 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:945571-946770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:952935-953435 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:963216-964415 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:966834-968033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:971810-972310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:972311-972811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:975802-976302 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:1007495-1008126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1008127-1008757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1011532-1012388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1016834-1017358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1020420-1020947 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1020948-1021474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1026287-1026787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1054437-1054938 Neighboring gene uncharacterized LOC124900249 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1058215-1059131 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:1082844-1083475 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1106443-1107642 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:1137192-1138391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1143844-1144350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1144351-1144856 Neighboring gene MPRA-validated peak6884 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1204552-1205230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1230934-1231434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1231435-1231935 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1232453-1232952 Neighboring gene Sharpr-MPRA regulatory region 9258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1246267-1247120 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1265413-1266612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1269351-1269851 Neighboring gene uncharacterized LOC124901869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1268850-1269350 Neighboring gene MPRA-validated peak6885 silencer Neighboring gene uncharacterized LOC286083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1298361-1298888 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1298889-1299416 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1308799-1309340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1321423-1321923 Neighboring gene keratinocyte proline-rich protein-like Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:1322036-1322849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1325138-1326080 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1365595-1365747 Neighboring gene uncharacterized LOC105377775 Neighboring gene uncharacterized LOC105379586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1385309-1385823 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1403885-1405084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1427697-1428250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1449675-1450203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1455237-1455738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1455739-1456238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1487477-1487978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1487979-1488478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1525979-1526505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1534609-1535108 Neighboring gene DLGAP2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:1552920-1554119 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:1555917-1556470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:1574652-1575623 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:1580608-1581807 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:1585200-1585433 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:1605998-1606719 Neighboring gene uncharacterized LOC124901870 Neighboring gene conserved acetylation island sequence 7 enhancer Neighboring gene DNA fragmentation factor subunit alpha pseudogene Neighboring gene uncharacterized LOC105377778 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:1703542-1704741 Neighboring gene CLN8 transmembrane ER and ERGIC protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-03-22)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-03-22)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
EBI GWAS Catalog
Genome-wide association study of age at menarche in African-American women.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in neuron-neuron synaptic transmission NAS
Non-traceable Author Statement
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neurofilament NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
disks large-associated protein 2
Names
ERICH1 antisense RNA 1 (non-protein coding)
ERICH1 antisense gene protein 1
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
discs large homolog associated protein 2
discs large-associated protein 2
putative DAP-2 like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009409.2 RefSeqGene

    Range
    4910..975758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346810.2NP_001333739.1  disks large-associated protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005010, AC026950, AC100797, AC110288, AC126333, AW195368
    Consensus CDS
    CCDS87572.1
    UniProtKB/Swiss-Prot
    A1QCF8, A1QCF9, A5D8Y2, O14488, O14664, Q9P1A6, Q9P1A7
    UniProtKB/TrEMBL
    A0A1B0GTN4
    Related
    ENSP00000489774.1, ENST00000637795.2

RNA

  1. NR_073397.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC100797, BC022082, HY026606
    Related
    ENST00000522092.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    737628..1708476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187565.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    206894..291612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187568.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    40534..279067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187572.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    19219..106180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187654.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    112159..317743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_187680.1 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    40124..121138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    529208..1487141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001277161.1: Suppressed sequence

    Description
    NM_001277161.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
  2. NM_004745.4: Suppressed sequence

    Description
    NM_004745.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.