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Dlgap2 DLG associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 244310, updated on 24-Jan-2023

Summary

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Official Symbol
Dlgap2provided by MGI
Official Full Name
DLG associated protein 2provided by MGI
Primary source
MGI:MGI:2443181
See related
Ensembl:ENSMUSG00000047495 AllianceGenome:MGI:2443181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dap2; Dap-2; Sapap2; 6430596N04Rik
Summary
Predicted to enable molecular adaptor activity and protein domain specific binding activity. Involved in regulation of postsynaptic neurotransmitter receptor activity. Predicted to be located in dendritic spine. Predicted to be active in glutamatergic synapse and postsynaptic specialization. Is expressed in cranium and nervous system. Orthologous to human DLGAP2 (DLG associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.2), frontal lobe adult (RPKM 3.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Dlgap2 in Genome Data Viewer
Location:
8; 8 A1.1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (14145793..14903426)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (14095776..14853426)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567547 Neighboring gene predicted gene, 53401 Neighboring gene predicted gene 5907 Neighboring gene glutamate rich 1 Neighboring gene high mobility group protein 1 pseudogene Neighboring gene predicted gene, 26184 Neighboring gene RIKEN cDNA C030037F17 gene Neighboring gene Rho guanine nucleotide exchange factor (GEF) 10 Neighboring gene CLN8 transmembrane ER and ERGIC protein Neighboring gene predicted gene, 35285

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence. Meng W, et al. Mol Psychiatry, 2021 Aug. PMID 31745236
  2. Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Jiang-Xie LF, et al. Mol Autism, 2014. PMID 25071926, Free PMC Article
  3. Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2. Horner AE, et al. Genes Brain Behav, 2021 Jan. PMID 33347690
  4. Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities. Schütt J, et al. J Biol Chem, 2009 Sep 18. PMID 19640847, Free PMC Article
  5. Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. Welch JM, et al. J Comp Neurol, 2004 Apr 19. PMID 15024750

See all (26) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.
    Title: Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence.
  2. Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
    Title: Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
  3. Semi-quantitative analysis of RNA levels in FMRP immunoprecipitates showed that in the mouse brain mRNAs encoding PSD components, such as Shank1, SAPAP1-3, PSD-95, and the glutamate receptor subunits NR1 and NR2B, are associated with FMRP.
    Title: Fragile X mental retardation protein regulates the levels of scaffold proteins and glutamate receptors in postsynaptic densities.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron-neuron synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density, intracellular component IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
disks large-associated protein 2
Names
PSD-95/SAP90-binding protein 2
SAP90/PSD-95 associated protein 2
discs, large homolog-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145965.1 → NP_001139437.1  disks large-associated protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001139437.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in an upstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a different and one amino acid longer N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK032564, BB622956, BC118969, CD773896
    Consensus CDS
    CCDS52491.1
    UniProtKB/Swiss-Prot
    Q8BJ42
    UniProtKB/TrEMBL
    Q0VF59
    Related
    ENSMUSP00000123078.2, ENSMUST00000152652.8
    Conserved Domains (1) summary
    pfam03359
    Location:716 → 1060
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. NM_172910.3 → NP_766498.2  disks large-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_766498.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a protein (isoform 1) of 1059aa.
    Source sequence(s)
    AK032564, AK082945, BC118969, CD773896
    Consensus CDS
    CCDS52492.1
    UniProtKB/Swiss-Prot
    Q6XBF3, Q8BJ42
    UniProtKB/TrEMBL
    Q0VF59, Q3V2X4
    Related
    ENSMUSP00000119613.2, ENSMUST00000133298.8
    Conserved Domains (1) summary
    pfam03359
    Location:715 → 1059
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    14145793..14903426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508783.5 → XP_006508846.1  disks large-associated protein 2 isoform X3

    Conserved Domains (1) summary
    pfam03359
    Location:716 → 1046
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  2. XM_036154017.1 → XP_036009910.1  disks large-associated protein 2 isoform X4

    Related
    ENSMUSP00000123104.2, ENSMUST00000150247.8
    Conserved Domains (1) summary
    pfam03359
    Location:715 → 1045
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  3. XM_006508781.5 → XP_006508844.1  disks large-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam03359
    Location:711 → 1055
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

  4. XM_006508782.5 → XP_006508845.1  disks large-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam03359
    Location:703 → 1047
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ42.2 GenPept UniProtKB/Swiss-Prot:Q8BJ42

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