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CD5L CD5 molecule like [ Homo sapiens (human) ]

Gene ID: 922, updated on 12-Aug-2018

Summary

Official Symbol
CD5Lprovided by HGNC
Official Full Name
CD5 molecule likeprovided by HGNC
Primary source
HGNC:HGNC:1690
See related
Ensembl:ENSG00000073754 MIM:602592; Vega:OTTHUMG00000022440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
Expression
Restricted expression toward spleen (RPKM 260.3) See more
Orthologs

Genomic context

See CD5L in Genome Data Viewer
Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (157827071..157841844, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157796861..157811634, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc receptor like 2 Neighboring gene Fc receptor like 1 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2 Neighboring gene Fc receptor like 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates CD5 molecule-like in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular defense response TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD5 antigen-like
Names
CD5 antigen-like (scavenger receptor cysteine rich family)
apoptosis inhibitor 6
apoptosis inhibitor expressed by macrophages
apoptosis inhibitor of macrophage
igM-associated peptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347698.1NP_001334627.1  CD5 antigen-like isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus compard to isoform 1.
    Source sequence(s)
    AL139409, AY358494, DA957550
    UniProtKB/Swiss-Prot
    O43866
  2. NM_005894.2NP_005885.1  CD5 antigen-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_005885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1, which differs only in the last aa compared to isoform 2.
    Source sequence(s)
    AK292040, AL139409, DA957550, U82812
    Consensus CDS
    CCDS1171.1
    UniProtKB/Swiss-Prot
    O43866
    Related
    ENSP00000357156.4, OTTHUMP00000024057, ENST00000368174.4, OTTHUMT00000058346
    Conserved Domains (1) summary
    smart00202
    Location:244346
    SR; Scavenger receptor Cys-rich

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    157827071..157841844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002806.1XP_016858295.1  CD5 antigen-like isoform X1

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