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CD5L CD5 molecule like [ Homo sapiens (human) ]

Gene ID: 922, updated on 1-Mar-2024

Summary

Official Symbol
CD5Lprovided by HGNC
Official Full Name
CD5 molecule likeprovided by HGNC
Primary source
HGNC:HGNC:1690
See related
Ensembl:ENSG00000073754 MIM:602592; AllianceGenome:HGNC:1690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward spleen (RPKM 260.3) See more
Orthologs
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Genomic context

See CD5L in Genome Data Viewer
Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157827068..157841808, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156964145..156978876, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157796858..157811598, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc receptor like 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene Fc receptor like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:157838349-157838995 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2 Neighboring gene Fc receptor like 4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
nucleocapsid gag HIV-1 NC upregulates CD5 molecule-like in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of complement-dependent cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of complement activation IEA
Inferred from Electronic Annotation
more info
 
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in blood microparticle HDA PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
CD5 antigen-like
Names
CD5 antigen-like (scavenger receptor cysteine rich family)
apoptosis inhibitor 6
apoptosis inhibitor expressed by macrophages
apoptosis inhibitor of macrophage
igM-associated peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347698.2NP_001334627.1  CD5 antigen-like isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus compard to isoform 1.
    Source sequence(s)
    AL139409, AY358494, DA957550
    UniProtKB/Swiss-Prot
    O43866
  2. NM_005894.3NP_005885.1  CD5 antigen-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_005885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1, which differs only in the last aa compared to isoform 2.
    Source sequence(s)
    AK292040, AL139409, DA957550, U82812
    Consensus CDS
    CCDS1171.1
    UniProtKB/Swiss-Prot
    A8K7M5, O43866, Q6UX63
    Related
    ENSP00000357156.4, ENST00000368174.5
    Conserved Domains (1) summary
    smart00202
    Location:244346
    SR; Scavenger receptor Cys-rich

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157827068..157841808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002806.2XP_016858295.1  CD5 antigen-like isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156964145..156978876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339616.1XP_054195591.1  CD5 antigen-like isoform X1