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IDI2 isopentenyl-diphosphate delta isomerase 2 [ Homo sapiens (human) ]

Gene ID: 91734, updated on 8-Jul-2021

Summary

Official Symbol
IDI2provided by HGNC
Official Full Name
isopentenyl-diphosphate delta isomerase 2provided by HGNC
Primary source
HGNC:HGNC:23487
See related
Ensembl:ENSG00000148377 MIM:615389
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPPI2
Summary
The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in adrenal (RPKM 2.6), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See IDI2 in Genome Data Viewer
Location:
10p15.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (1018910..1025859, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (1064850..1071799, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984285 Neighboring gene uncharacterized LOC105376341 Neighboring gene Sharpr-MPRA regulatory region 2332 Neighboring gene GTP binding protein 4 Neighboring gene IDI2 antisense RNA 1 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene WD repeat domain 37 Neighboring gene uncharacterized LOC105376344

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables isopentenyl-diphosphate delta-isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
isopentenyl-diphosphate delta-isomerase 2
Names
IPP isomerase 2
diphosphate dimethylallyl diphosphate isomerase 2
isopentenyl pyrophosphate isomerase 2
isopentenyl-diphosphate Delta-isomerase 2
NP_150286.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033261.3NP_150286.1  isopentenyl-diphosphate delta-isomerase 2

    See identical proteins and their annotated locations for NP_150286.1

    Status: REVIEWED

    Source sequence(s)
    AC022536
    Consensus CDS
    CCDS7055.1
    UniProtKB/Swiss-Prot
    Q9BXS1
    Related
    ENSP00000277517.1, ENST00000277517.2
    Conserved Domains (1) summary
    cl00447
    Location:6227
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    1018910..1025859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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