U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IDI2 isopentenyl-diphosphate delta isomerase 2 [ Homo sapiens (human) ]

Gene ID: 91734, updated on 27-Nov-2024

Summary

Official Symbol
IDI2provided by HGNC
Official Full Name
isopentenyl-diphosphate delta isomerase 2provided by HGNC
Primary source
HGNC:HGNC:23487
See related
Ensembl:ENSG00000148377 MIM:615389; AllianceGenome:HGNC:23487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPPI2
Summary
The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in adrenal (RPKM 2.6), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IDI2 in Genome Data Viewer
Location:
10p15.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (1018910..1025859, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (1016077..1023009, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (1064850..1071799, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog C Neighboring gene uncharacterized LOC124902361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:696476-697298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:709923-710450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:717375-717875 Neighboring gene DIP2C antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:735983-736918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:745902-746402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:746403-746903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:771745-772245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:791683-792184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:792185-792684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:805871-806370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:833618-834539 Neighboring gene HNF4 motif-containing MPRA enhancer 225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:855735-856235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:855234-855734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:860152-860652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:860653-861153 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:879525-879763 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17861 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:908856-909700 Neighboring gene La ribonucleoprotein 4B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2062 Neighboring gene keratinocyte proline-rich protein-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:989167-989668 Neighboring gene LARP4B divergent transcript Neighboring gene Sharpr-MPRA regulatory region 2332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1036121-1037016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1050745-1051244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1054558-1055058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1055059-1055559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2894 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:1088961-1090160 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr10:1094306-1094836 and GRCh37_chr10:1094837-1095366 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1095367-1095896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2897 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2066 Neighboring gene GTP binding protein 4 Neighboring gene IDI2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1130525-1131024 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:1141578-1142777 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1148139-1148671 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:1155609-1156808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1163429-1163930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:1167102-1167742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1166460-1167101 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1196487-1196986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1199503-1200004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1200005-1200504 Neighboring gene uncharacterized LOC105376344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:1201744-1202634 Neighboring gene WD repeat domain 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables isopentenyl-diphosphate delta-isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables isopentenyl-diphosphate delta-isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
isopentenyl-diphosphate delta-isomerase 2
Names
IPP isomerase 2
diphosphate dimethylallyl diphosphate isomerase 2
isopentenyl pyrophosphate isomerase 2
isopentenyl-diphosphate Delta-isomerase 2
NP_150286.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033261.3NP_150286.1  isopentenyl-diphosphate delta-isomerase 2

    See identical proteins and their annotated locations for NP_150286.1

    Status: REVIEWED

    Source sequence(s)
    AC022536
    Consensus CDS
    CCDS7055.1
    UniProtKB/Swiss-Prot
    Q9BXS1
    Related
    ENSP00000277517.1, ENST00000277517.2
    Conserved Domains (1) summary
    cl00447
    Location:6227
    Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    1018910..1025859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    1016077..1023009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)