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LPAR2 lysophosphatidic acid receptor 2 [ Homo sapiens (human) ]

Gene ID: 9170, updated on 22-May-2020

Summary

Official Symbol
LPAR2provided by HGNC
Official Full Name
lysophosphatidic acid receptor 2provided by HGNC
Primary source
HGNC:HGNC:3168
See related
Ensembl:ENSG00000064547 MIM:605110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDG4; LPA2; EDG-4; LPA-2
Summary
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 11.9), bone marrow (RPKM 11.1) and 22 other tissues See more
Orthologs

Genomic context

See LPAR2 in Genome Data Viewer
Location:
19p13.11
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (19623655..19628395, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19734464..19739039, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4095 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene PBX homeobox 4 Neighboring gene PHD finger protein 5C pseudogene Neighboring gene GEM interacting protein Neighboring gene ATPase 13A1 Neighboring gene conserved acetylation island sequence C14 enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of lysophosphatidic acid receptor 2 (LPAR2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ93869

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
lipid binding TAS
Traceable Author Statement
more info
PubMed 
lysophosphatidic acid receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
lysophosphatidic acid receptor 2
Names
G protein-coupled receptor
LPA receptor 2
LPA receptor EDG4
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
lysophosphatidic acid receptor EDG4
lysophosphatidic acid receptor Edg-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004720.7NP_004711.2  lysophosphatidic acid receptor 2

    See identical proteins and their annotated locations for NP_004711.2

    Status: REVIEWED

    Source sequence(s)
    AC011458
    Consensus CDS
    CCDS12407.1
    UniProtKB/Swiss-Prot
    Q9HBW0
    UniProtKB/TrEMBL
    A0A024R7M9
    Related
    ENSP00000384665.2, ENST00000407877.8
    Conserved Domains (2) summary
    cd14964
    Location:3559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    19623655..19628395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027468.2XP_016882957.1  lysophosphatidic acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBW0
    UniProtKB/TrEMBL
    A0A024R7M9
    Related
    ENSP00000443256.1, ENST00000542587.5
    Conserved Domains (2) summary
    cd14964
    Location:3559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_017027469.1XP_016882958.1  lysophosphatidic acid receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9HBW0
    UniProtKB/TrEMBL
    A0A024R7M9
    Conserved Domains (2) summary
    cd14964
    Location:3559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_024451774.1XP_024307542.1  lysophosphatidic acid receptor 2 isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:3559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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