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PDCD5 programmed cell death 5 [ Homo sapiens (human) ]

Gene ID: 9141, updated on 13-Mar-2020

Summary

Official Symbol
PDCD5provided by HGNC
Official Full Name
programmed cell death 5provided by HGNC
Primary source
HGNC:HGNC:8764
See related
Ensembl:ENSG00000105185 MIM:604583
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFAR19
Summary
This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in testis (RPKM 17.5), adrenal (RPKM 13.5) and 25 other tissues See more
Orthologs

Genomic context

See PDCD5 in Genome Data Viewer
Location:
19q13.11
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (32581190..32587453)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (33072071..33078358)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC400684 Neighboring gene dpy-19 like C-mannosyltransferase 3 Neighboring gene ankyrin repeat domain 27 Neighboring gene small nucleolar RNA, H/ACA box 68B Neighboring gene ribosomal protein S12 pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9294, FLJ42784

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
acetyltransferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
beta-tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
programmed cell death protein 5
Names
TF-1 cell apoptosis-related protein 19
TF1 cell apoptosis-related gene 19
TFAR19 novel apoptosis-related

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004708.4NP_004699.1  programmed cell death protein 5

    See identical proteins and their annotated locations for NP_004699.1

    Status: REVIEWED

    Source sequence(s)
    AC008474, BC015519, DN915905, N40187
    Consensus CDS
    CCDS12423.1
    UniProtKB/Swiss-Prot
    O14737
    Related
    ENSP00000466214.1, ENST00000590247.7
    Conserved Domains (1) summary
    pfam01984
    Location:9113
    dsDNA_bind; Double-stranded DNA-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    32581190..32587453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259392.5XP_005259449.1  programmed cell death protein 5 isoform X1

    See identical proteins and their annotated locations for XP_005259449.1

    UniProtKB/Swiss-Prot
    O14737
    Related
    ENSP00000476525.1, ENST00000419343.7
    Conserved Domains (1) summary
    pfam01984
    Location:995
    dsDNA_bind; Double-stranded DNA-binding domain
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