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SESTD1 SEC14 and spectrin domain containing 1 [ Homo sapiens (human) ]

Gene ID: 91404, updated on 23-Nov-2021

Summary

Official Symbol
SESTD1provided by HGNC
Official Full Name
SEC14 and spectrin domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18379
See related
Ensembl:ENSG00000187231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOLO
Expression
Ubiquitous expression in fat (RPKM 11.0), lung (RPKM 7.2) and 24 other tissues See more
Orthologs
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Genomic context

See SESTD1 in Genome Data Viewer
Location:
2q31.2
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (179101678..179264832, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (179966405..180129559, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373766 Neighboring gene coiled-coil domain containing 141 Neighboring gene ribosomal protein S6 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 1228 Neighboring gene RAD52 pseudogene 1 Neighboring gene zinc finger protein 385B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of antiphospholipid antibodies.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SEC14 and spectrin domains 1 (SESTD1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434O0515

General protein information

Preferred Names
SEC14 domain and spectrin repeat-containing protein 1
Names
SEC14 and spectrin domains 1
huntingtin-interacting protein-like protein
protein Solo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178123.5NP_835224.3  SEC14 domain and spectrin repeat-containing protein 1

    See identical proteins and their annotated locations for NP_835224.3

    Status: VALIDATED

    Source sequence(s)
    AC016755, AC093911, AK096232, AY209190, BC047578
    Consensus CDS
    CCDS33338.1
    UniProtKB/Swiss-Prot
    Q86VW0
    UniProtKB/TrEMBL
    B3KTX3
    Related
    ENSP00000415332.2, ENST00000428443.8
    Conserved Domains (2) summary
    pfam13716
    Location:33153
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
    cl02488
    Location:273478
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    179101678..179264832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005251.1XP_016860740.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X4

  2. XM_017005250.1XP_016860739.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X2

    Conserved Domains (2) summary
    pfam13716
    Location:28147
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
    cl02488
    Location:273478
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. XM_011512139.2XP_011510441.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011510441.1

    UniProtKB/Swiss-Prot
    Q86VW0
    Conserved Domains (2) summary
    pfam13716
    Location:33153
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
    cl02488
    Location:273478
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. XM_011512141.2XP_011510443.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X3

    Conserved Domains (2) summary
    pfam13716
    Location:171
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
    cl02488
    Location:191396
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RNA

  1. XR_001739032.1 RNA Sequence

  2. XR_001739031.1 RNA Sequence

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