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FAM50A family with sequence similarity 50 member A [ Homo sapiens (human) ]

Gene ID: 9130, updated on 8-Jul-2021

Summary

Official Symbol
FAM50Aprovided by HGNC
Official Full Name
family with sequence similarity 50 member Aprovided by HGNC
Primary source
HGNC:HGNC:18786
See related
Ensembl:ENSG00000071859 MIM:300453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
9F; XAP5; HXC26; MRXSA; HXC-26; DXS9928E
Summary
This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. [provided by RefSeq, Sep 2009]
Expression
Ubiquitous expression in fat (RPKM 32.0), placenta (RPKM 25.3) and 25 other tissues See more
Orthologs
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Genomic context

See FAM50A in Genome Data Viewer
Location:
Xq28
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154444141..154450654)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153672488..153679002)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting accessory protein 1 Neighboring gene GDP dissociation inhibitor 1 Neighboring gene microRNA 6858 Neighboring gene plexin A3 Neighboring gene L antigen family member 3 Neighboring gene ubiquitin like 4A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein FAM50A
Names
protein XAP-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013233.1 RefSeqGene

    Range
    5004..11518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004699.4NP_004690.1  protein FAM50A

    See identical proteins and their annotated locations for NP_004690.1

    Status: REVIEWED

    Source sequence(s)
    BQ018378, CR992165, D83260
    Consensus CDS
    CCDS14751.1
    UniProtKB/Swiss-Prot
    Q14320
    Related
    ENSP00000377225.3, ENST00000393600.8
    Conserved Domains (1) summary
    pfam04921
    Location:152338
    XAP5; circadian clock regulator

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154444141..154450654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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