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Fam50a family with sequence similarity 50, member A [ Mus musculus (house mouse) ]

Gene ID: 108160, updated on 8-Apr-2026
Official Symbol
Fam50aprovided by MGI
Official Full Name
family with sequence similarity 50, member Aprovided by MGI
Primary source
MGI:MGI:1351626
See related
Ensembl:ENSMUSG00000001962 AllianceGenome:MGI:1351626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
XAP-5; D0HXS9928E
Summary
Predicted to be involved in chromatin organization and regulation of RNA splicing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Armfield syndrome. Orthologous to human FAM50A (family with sequence similarity 50 member A). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 17.7), CNS E11.5 (RPKM 17.2) and 27 other tissues See more
Orthologs
all
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See Fam50a in Genome Data Viewer
Location:
X A7.3; X 37.98 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73356589..73363761)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74313033..74320149)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7694 Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1 Neighboring gene GDP dissociation inhibitor 1 Neighboring gene microRNA 7092 Neighboring gene predicted gene, 39520 Neighboring gene plexin A3 Neighboring gene L antigen family, member 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The Fam50a positively regulates ameloblast differentiation via interacting with Runx2. Kim Y, et al. J Cell Physiol, 2018 Feb. PMID 28574578
  2. Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors. Wang W, et al. Elife, 2025 Feb 26. PMID 40009443, Free PMC Article
  3. Human and mouse XAP-5 and XAP-5-like (X5L) genes: identification of an ancient functional retroposon differentially expressed in testis. Sedlacek Z, et al. Genomics, 1999 Oct 15. PMID 10534398
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
protein FAM50A
Names
protein XAP-5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138607.3 → NP_613073.2  protein FAM50A

    See identical proteins and their annotated locations for NP_613073.2

    Status: VALIDATED

    Source sequence(s)
    AK008402, Y18505
    Consensus CDS
    CCDS41021.1
    UniProtKB/Swiss-Prot
    Q9D866, Q9WV03
    UniProtKB/TrEMBL
    A0A158SIT3
    Related
    ENSMUSP00000109797.2, ENSMUST00000114160.2
    Conserved Domains (1) summary
    pfam04921
    Location:152 → 338
    XAP5; circadian clock regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73356589..73363761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161770.1 → XP_036017663.1  protein FAM50A isoform X1

    UniProtKB/Swiss-Prot
    Q9D866, Q9WV03
    UniProtKB/TrEMBL
    A0A158SIT3
    Conserved Domains (1) summary
    pfam04921
    Location:152 → 338
    XAP5; circadian clock regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV03.1 GenPept UniProtKB/Swiss-Prot:Q9WV03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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