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SLC16A6 solute carrier family 16 member 6 [ Homo sapiens (human) ]

Gene ID: 9120, updated on 24-Nov-2020

Summary

Official Symbol
SLC16A6provided by HGNC
Official Full Name
solute carrier family 16 member 6provided by HGNC
Primary source
HGNC:HGNC:10927
See related
Ensembl:ENSG00000108932 MIM:603880
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT6; MCT7
Expression
Broad expression in esophagus (RPKM 4.8), appendix (RPKM 3.2) and 18 other tissues See more
Orthologs

Genomic context

See SLC16A6 in Genome Data Viewer
Location:
17q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (68267026..68291439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (66263167..66287405, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 27 pseudogene 2 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene arylsulfatase G Neighboring gene tRNA-undetermined (NNN) 5-1 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha Neighboring gene microRNA 635 Neighboring gene WD repeat domain, phosphoinositide interacting 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of solute carrier family 16, member 6 (SLC16A6) in Vif-expression T cells PubMed
capsid gag Depletion of the SLC16A6 expression upregulates HIV-1 CA A92E mutant infectivity in CsA-untreated HeLa cells and downregulates its infectivity in CsA-treated HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
monocarboxylate transporter 7
Names
breast cancer protein BCY5
monocarboxylate transporter 6
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001174166.2NP_001167637.1  monocarboxylate transporter 7

    See identical proteins and their annotated locations for NP_001167637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AC005332, BC064832, U79745
    Consensus CDS
    CCDS11675.1
    UniProtKB/Swiss-Prot
    O15403
    UniProtKB/TrEMBL
    A0A024R8J3
    Related
    ENSP00000319991.4, ENST00000327268.8
    Conserved Domains (1) summary
    cl26868
    Location:19508
    2A0111; oxalate/formate antiporter family transporter
  2. NM_004694.5NP_004685.2  monocarboxylate transporter 7

    See identical proteins and their annotated locations for NP_004685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC005332, BC064832
    Consensus CDS
    CCDS11675.1
    UniProtKB/Swiss-Prot
    O15403
    UniProtKB/TrEMBL
    A0A024R8J3
    Related
    ENSP00000462985.1, ENST00000580666.6
    Conserved Domains (1) summary
    cl26868
    Location:19508
    2A0111; oxalate/formate antiporter family transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    68267026..68291439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451021.1XP_024306789.1  monocarboxylate transporter 7 isoform X1

    Conserved Domains (1) summary
    cl26868
    Location:19508
    2A0111; oxalate/formate antiporter family transporter
  2. XM_011525461.3XP_011523763.1  monocarboxylate transporter 7 isoform X1

    See identical proteins and their annotated locations for XP_011523763.1

    UniProtKB/Swiss-Prot
    O15403
    UniProtKB/TrEMBL
    A0A024R8J3
    Related
    ENSP00000480820.1, ENST00000620436.4
    Conserved Domains (1) summary
    cl26868
    Location:19508
    2A0111; oxalate/formate antiporter family transporter
  3. XM_017025291.2XP_016880780.1  monocarboxylate transporter 7 isoform X1

    UniProtKB/Swiss-Prot
    O15403
    UniProtKB/TrEMBL
    A0A024R8J3
    Conserved Domains (1) summary
    cl26868
    Location:19508
    2A0111; oxalate/formate antiporter family transporter
  4. XM_017025292.2XP_016880781.1  monocarboxylate transporter 7 isoform X1

    UniProtKB/Swiss-Prot
    O15403
    UniProtKB/TrEMBL
    A0A024R8J3
    Conserved Domains (1) summary
    cl26868
    Location:19508
    2A0111; oxalate/formate antiporter family transporter
  5. XM_005257789.4XP_005257846.2  monocarboxylate transporter 7 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:33476
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:23512
    2A0113; monocarboxylate transporter 1
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