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LATS1 large tumor suppressor kinase 1 [ Homo sapiens (human) ]

Gene ID: 9113, updated on 11-Sep-2019

Summary

Official Symbol
LATS1provided by HGNC
Official Full Name
large tumor suppressor kinase 1provided by HGNC
Primary source
HGNC:HGNC:6514
See related
Ensembl:ENSG00000131023 MIM:603473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
wts; WARTS
Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See LATS1 in Genome Data Viewer
Location:
6q25.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149658153..149718256, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149979289..150039392, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18 pseudogene 9 Neighboring gene katanin catalytic subunit A1 Neighboring gene uncharacterized LOC105378050 Neighboring gene uncharacterized LOC645967 Neighboring gene nucleoporin 43 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase Neighboring gene BTB domain containing 10 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Hippo signaling, organism-specific biosystem (from KEGG)
    Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling, conserved biosystem (from KEGG)
    Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic sequestering of protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
hormone-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
inner cell mass cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
inner cell mass cellular morphogenesis IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
mammary gland epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
sister chromatid segregation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase LATS1
Names
LATS (large tumor suppressor, Drosophila) homolog 1
LATS, large tumor suppressor, homolog 1
WARTS protein kinase
h-warts
large tumor suppressor homolog 1
NP_001257448.1
NP_001337268.1
NP_001337269.1
NP_001337321.1
NP_004681.1
XP_006715666.1
XP_011534554.1
XP_016866963.1
XP_016866966.1
XP_016866968.1
XP_016866969.1
XP_016866971.1
XP_024302351.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270519.1NP_001257448.1  serine/threonine-protein kinase LATS1 isoform 2

    See identical proteins and their annotated locations for NP_001257448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF104413, AL358852, AL583963, BC002767
    Consensus CDS
    CCDS59040.1
    UniProtKB/Swiss-Prot
    O95835
    Related
    ENSP00000444678.1, ENST00000392273.7
    Conserved Domains (3) summary
    cd14397
    Location:103143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl26247
    Location:473558
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl28087
    Location:467673
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. NM_001350339.2NP_001337268.1  serine/threonine-protein kinase LATS1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform 3.
    Source sequence(s)
    AL358852, AL583963, BX276089
    Conserved Domains (3) summary
    cl21453
    Location:5981012
    PKc_like; Protein Kinases, catalytic domain
    cl21463
    Location:1138
    UBA_like_SF; UBA domain-like superfamily
    cl28087
    Location:343491
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  3. NM_001350340.2NP_001337269.1  serine/threonine-protein kinase LATS1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform 4.
    Source sequence(s)
    AL358852, AL583963, BX276089
    Conserved Domains (3) summary
    cd05625
    Location:598979
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl21463
    Location:1138
    UBA_like_SF; UBA domain-like superfamily
    cl28087
    Location:343491
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  4. NM_001350392.2NP_001337321.1  serine/threonine-protein kinase LATS1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes isoform 5.
    Source sequence(s)
    AL358852, AL583963, BX276089
    Conserved Domains (2) summary
    cd05625
    Location:423804
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1
    cl26464
    Location:9312
    Atrophin-1; Atrophin-1 family
  5. NM_004690.4NP_004681.1  serine/threonine-protein kinase LATS1 isoform 1

    See identical proteins and their annotated locations for NP_004681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF104413, AL358852, AW021064, BX276089
    Consensus CDS
    CCDS34551.1
    UniProtKB/Swiss-Prot
    O95835
    Related
    ENSP00000437550.1, ENST00000543571.6
    Conserved Domains (3) summary
    smart00220
    Location:7051010
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14397
    Location:103143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cd05625
    Location:7031084
    STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

RNA

  1. NR_073033.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
    Source sequence(s)
    AK310422, AW021064, BX276089

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149658153..149718256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011474.1XP_016866963.1  serine/threonine-protein kinase LATS1 isoform X1

    Conserved Domains (3) summary
    cd14397
    Location:103143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:7031117
    PKc_like; Protein Kinases, catalytic domain
    cl28087
    Location:448596
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  2. XM_017011480.1XP_016866969.1  serine/threonine-protein kinase LATS1 isoform X6

  3. XM_024446583.1XP_024302351.1  serine/threonine-protein kinase LATS1 isoform X1

    Conserved Domains (3) summary
    cd14397
    Location:103143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:7031117
    PKc_like; Protein Kinases, catalytic domain
    cl28087
    Location:448596
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
  4. XM_017011479.1XP_016866968.1  serine/threonine-protein kinase LATS1 isoform X4

  5. XM_017011477.1XP_016866966.1  serine/threonine-protein kinase LATS1 isoform X2

  6. XM_011536252.2XP_011534554.1  serine/threonine-protein kinase LATS1 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:705961
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14397
    Location:103143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:703961
    PKc_like; Protein Kinases, catalytic domain
  7. XM_006715603.3XP_006715666.1  serine/threonine-protein kinase LATS1 isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:705862
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14397
    Location:103143
    UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1
    cl21453
    Location:703863
    PKc_like; Protein Kinases, catalytic domain
  8. XM_017011482.1XP_016866971.1  serine/threonine-protein kinase LATS1 isoform X7

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