Format

Send to:

Choose Destination

USP6 ubiquitin specific peptidase 6 [ Homo sapiens (human) ]

Gene ID: 9098, updated on 12-Oct-2019

Summary

Official Symbol
USP6provided by HGNC
Official Full Name
ubiquitin specific peptidase 6provided by HGNC
Primary source
HGNC:HGNC:12629
See related
Ensembl:ENSG00000129204 MIM:604334
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRP1; TRE2; TRE17; Tre-2; TRESMCR; USP6-short
Expression
Biased expression in testis (RPKM 9.4), ovary (RPKM 2.5) and 9 other tissues See more
Orthologs

Genomic context

See USP6 in Genome Data Viewer
Location:
17p13.2
Exon count:
41
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (5116032..5175032)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (5031687..5078327)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928000 Neighboring gene ZFP3 zinc finger protein Neighboring gene zinc finger protein 232 Neighboring gene uncharacterized LOC100130950 Neighboring gene zinc finger protein 594 Neighboring gene SLP adaptor and CSK interacting membrane protein Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene uncharacterized LOC105371505

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquitin specific peptidase 6 (USP6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
nucleic acid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein modification process NAS
Non-traceable Author Statement
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 6
Names
TBC1D3 and USP32 fusion
deubiquitinating enzyme 6
hyperpolymorphic gene 1
proto-oncogene TRE-2
ubiquitin specific peptidase 6 (Tre-2 oncogene)
ubiquitin specific protease 6 (Tre-2 oncogene)
ubiquitin thioesterase 6
ubiquitin thiolesterase 6
ubiquitin-specific protease USP6
ubiquitin-specific-processing protease 6
NP_001291213.1
NP_004496.2
XP_011522352.1
XP_011522353.1
XP_011522354.1
XP_011522355.1
XP_011522356.1
XP_011522357.1
XP_011522358.1
XP_011522359.1
XP_011522360.1
XP_011522361.1
XP_016880779.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304284.2NP_001291213.1  ubiquitin carboxyl-terminal hydrolase 6

    See identical proteins and their annotated locations for NP_001291213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC012146
    Consensus CDS
    CCDS11069.2
    UniProtKB/Swiss-Prot
    P35125
    Related
    ENSP00000460380.1, ENST00000574788.5
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  2. NM_004505.4NP_004496.2  ubiquitin carboxyl-terminal hydrolase 6

    See identical proteins and their annotated locations for NP_004496.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC012146
    Consensus CDS
    CCDS11069.2
    UniProtKB/Swiss-Prot
    P35125
    Related
    ENSP00000250066.6, ENST00000250066.6
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    5116032..5175032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524050.1XP_011522352.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522352.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  2. XM_011524057.2XP_011522359.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X2

    Conserved Domains (4) summary
    smart00164
    Location:97290
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5061092
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10011345
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:310385
    DUF4607; Domain of unknown function (DUF4607)
  3. XM_011524055.2XP_011522357.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522357.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  4. XM_011524053.2XP_011522355.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522355.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  5. XM_011524051.2XP_011522353.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522353.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  6. XM_011524054.2XP_011522356.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522356.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  7. XM_011524058.2XP_011522360.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X3

    Conserved Domains (3) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl02553
    Location:533723
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  8. XM_011524059.2XP_011522361.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X4

    UniProtKB/Swiss-Prot
    P35125
    Related
    ENSP00000461581.1, ENST00000572949.5
    Conserved Domains (3) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl02553
    Location:533723
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  9. XM_011524052.2XP_011522354.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522354.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  10. XM_017025290.1XP_016880779.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)
  11. XM_011524056.2XP_011522358.1  ubiquitin carboxyl-terminal hydrolase 6 isoform X1

    See identical proteins and their annotated locations for XP_011522358.1

    UniProtKB/Swiss-Prot
    P35125
    Conserved Domains (4) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG5560
    Location:5281114
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:10231367
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam15380
    Location:332407
    DUF4607; Domain of unknown function (DUF4607)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005152.1: Suppressed sequence

    Description
    NM_005152.1: This RefSeq was permanently suppressed because it contains the wrong CDS and is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center