U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADCK2 aarF domain containing kinase 2 [ Homo sapiens (human) ]

Gene ID: 90956, updated on 6-Nov-2022

Summary

Official Symbol
ADCK2provided by HGNC
Official Full Name
aarF domain containing kinase 2provided by HGNC
Primary source
HGNC:HGNC:19039
See related
Ensembl:ENSG00000133597 AllianceGenome:HGNC:19039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AARF
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 8.8), brain (RPKM 7.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ADCK2 in Genome Data Viewer
Location:
7q34
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140672945..140695110)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141987120..142009286)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140372745..140394910)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene Sharpr-MPRA regulatory region 2153 Neighboring gene uncharacterized LOC105375535 Neighboring gene RNA, 7SL, cytoplasmic 771, pseudogene Neighboring gene NDUFB2 antisense RNA 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene B-Raf proto-oncogene, serine/threonine kinase Neighboring gene RNA, U6 small nuclear 85, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20727

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uncharacterized aarF domain-containing protein kinase 2
Names
putative ubiquinone biosynthesis protein AarF

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052853.4NP_443085.2  uncharacterized aarF domain-containing protein kinase 2

    See identical proteins and their annotated locations for NP_443085.2

    Status: VALIDATED

    Source sequence(s)
    AC006344, AC006452, AY302592
    Consensus CDS
    CCDS5861.1
    UniProtKB/Swiss-Prot
    Q7Z695, Q9Y6T5
    UniProtKB/TrEMBL
    A4D1T6
    Related
    ENSP00000072869.4, ENST00000072869.9
    Conserved Domains (2) summary
    COG0661
    Location:134618
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13971
    Location:169553
    ADCK2-like; aarF domain containing kinase 2 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    140672945..140695110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716170.5XP_006716233.1  uncharacterized aarF domain-containing protein kinase 2 isoform X2

    Conserved Domains (2) summary
    COG0661
    Location:134534
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cl21453
    Location:169469
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011516675.4XP_011514977.1  uncharacterized aarF domain-containing protein kinase 2 isoform X1

    Conserved Domains (2) summary
    COG0661
    Location:134586
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13971
    Location:169521
    ADCK2-like; aarF domain containing kinase 2 and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    141987120..142009286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)