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Adck2 aarF domain containing kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 57869, updated on 2-Nov-2024

Summary

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Official Symbol
Adck2provided by MGI
Official Full Name
aarF domain containing kinase 2provided by MGI
Primary source
MGI:MGI:1889336
See related
Ensembl:ENSMUSG00000046947 AllianceGenome:MGI:1889336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study mitochondrial myopathy. Orthologous to human ADCK2 (aarF domain containing kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.2), ovary adult (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Adck2 in Genome Data Viewer
Location:
6 B1; 6 18.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39550778..39565703)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39573844..39588769)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene predicted gene, 52860 Neighboring gene STARR-seq mESC enhancer starr_15661 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene Braf transforming gene Neighboring gene predicted gene, 34389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency. Vázquez-Fonseca L, et al. J Clin Med, 2019 Sep 2. PMID 31480808, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ubiquinone biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uncharacterized aarF domain-containing protein kinase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178873.3 → NP_849204.1  uncharacterized aarF domain-containing protein kinase 2

    See identical proteins and their annotated locations for NP_849204.1

    Status: PROVISIONAL

    Source sequence(s)
    AK028568
    Consensus CDS
    CCDS20024.1
    UniProtKB/Swiss-Prot
    Q3TTS5, Q6NSR3, Q8BHC6
    UniProtKB/TrEMBL
    A0A0R4J1X6
    Related
    ENSMUSP00000123563.2, ENSMUST00000140364.8
    Conserved Domains (2) summary
    cd13971
    Location:169 → 544
    ADCK2-like; aarF domain containing kinase 2 and similar proteins
    TIGR01982
    Location:98 → 609
    UbiB; 2-polyprenylphenol 6-hydroxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39550778..39565703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506425.3 → XP_006506488.1  uncharacterized aarF domain-containing protein kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:169 → 430
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSR3.1 GenPept UniProtKB/Swiss-Prot:Q6NSR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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