U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adck2 aarF domain containing kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 57869, updated on 28-Oct-2024

Summary

Official Symbol
Adck2provided by MGI
Official Full Name
aarF domain containing kinase 2provided by MGI
Primary source
MGI:MGI:1889336
See related
Ensembl:ENSMUSG00000046947 AllianceGenome:MGI:1889336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study mitochondrial myopathy. Orthologous to human ADCK2 (aarF domain containing kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 10.2), ovary adult (RPKM 9.1) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Adck2 in Genome Data Viewer
Location:
6 B1; 6 18.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39550778..39565703)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39573844..39588769)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene predicted gene, 52860 Neighboring gene STARR-seq mESC enhancer starr_15661 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene Braf transforming gene Neighboring gene predicted gene, 34389

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ubiquinone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
uncharacterized aarF domain-containing protein kinase 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178873.3NP_849204.1  uncharacterized aarF domain-containing protein kinase 2

    See identical proteins and their annotated locations for NP_849204.1

    Status: PROVISIONAL

    Source sequence(s)
    AK028568
    Consensus CDS
    CCDS20024.1
    UniProtKB/Swiss-Prot
    Q3TTS5, Q6NSR3, Q8BHC6
    UniProtKB/TrEMBL
    A0A0R4J1X6
    Related
    ENSMUSP00000123563.2, ENSMUST00000140364.8
    Conserved Domains (2) summary
    cd13971
    Location:169544
    ADCK2-like; aarF domain containing kinase 2 and similar proteins
    TIGR01982
    Location:98609
    UbiB; 2-polyprenylphenol 6-hydroxylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    39550778..39565703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506425.3XP_006506488.1  uncharacterized aarF domain-containing protein kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:169430
    PKc_like; Protein Kinases, catalytic domain