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TRIM41 tripartite motif containing 41 [ Homo sapiens (human) ]

Gene ID: 90933, updated on 17-Dec-2019

Summary

Official Symbol
TRIM41provided by HGNC
Official Full Name
tripartite motif containing 41provided by HGNC
Primary source
HGNC:HGNC:19013
See related
Ensembl:ENSG00000146063 MIM:610530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RINCK
Summary
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase C signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis (RPKM 14.3), brain (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See TRIM41 in Genome Data Viewer
Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (181223265..181235808)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180650263..180662808)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tRNA-Val (anticodon CAC) 1-5 Neighboring gene microRNA 4638 Neighboring gene receptor for activated C kinase 1 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1127, MGC31991

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to muramyl dipeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM41
Names
RING finger-interacting protein with C kinase
RING-finger protein that interacts with C kinase
RING-type E3 ubiquitin transferase TRIM41
NP_291027.3
NP_963921.1
XP_006714992.1
XP_006714993.1
XP_006714994.1
XP_006714995.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030346.1 RefSeqGene

    Range
    5019..17546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_033549.5NP_291027.3  E3 ubiquitin-protein ligase TRIM41 isoform 1

    See identical proteins and their annotated locations for NP_291027.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also referred to as alpha) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC018765, BC090953, DA341383
    Consensus CDS
    CCDS4466.1
    UniProtKB/Swiss-Prot
    Q8WV44
    Related
    ENSP00000320869.5, ENST00000315073.10
    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd13741
    Location:432630
    SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_201627.3NP_963921.1  E3 ubiquitin-protein ligase TRIM41 isoform 2

    See identical proteins and their annotated locations for NP_963921.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also referred to as beta) includes several alternate exons and an alternate splice pattern in the 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which has a distinct C-terminus, compared to isoform.
    Source sequence(s)
    AK027601, BC018765, BC090953, DA341383
    Consensus CDS
    CCDS4465.1
    UniProtKB/Swiss-Prot
    Q8WV44
    Related
    ENSP00000336749.6, ENST00000351937.9
    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02614
    Location:432489
    SPRY; SPRY domain
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. NR_045218.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes several alternate exons and an alternate splice pattern, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK027601, BC004956, BC018765, DA341383

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    181223265..181235808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714932.3XP_006714995.1  E3 ubiquitin-protein ligase TRIM41 isoform X4

    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02614
    Location:432498
    SPRY; SPRY domain
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_006714931.3XP_006714994.1  E3 ubiquitin-protein ligase TRIM41 isoform X3

    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02614
    Location:432491
    SPRY; SPRY domain
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_006714929.2XP_006714992.1  E3 ubiquitin-protein ligase TRIM41 isoform X1

    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02614
    Location:432498
    SPRY; SPRY domain
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. XM_006714930.2XP_006714993.1  E3 ubiquitin-protein ligase TRIM41 isoform X2

    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl02614
    Location:432489
    SPRY; SPRY domain
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. XR_941119.2 RNA Sequence

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