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Trim41 tripartite motif-containing 41 [ Mus musculus (house mouse) ]

Gene ID: 211007, updated on 5-Mar-2024

Summary

Official Symbol
Trim41provided by MGI
Official Full Name
tripartite motif-containing 41provided by MGI
Primary source
MGI:MGI:2384814
See related
Ensembl:ENSMUSG00000040365 AllianceGenome:MGI:2384814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RINCK
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; cellular response to muramyl dipeptide; and positive regulation of DNA-binding transcription factor activity. Predicted to be located in nucleolus. Predicted to be active in cytoplasm and nuclear body. Orthologous to human TRIM41 (tripartite motif containing 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 35.3), adrenal adult (RPKM 16.3) and 28 other tissues See more
Orthologs
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Genomic context

See Trim41 in Genome Data Viewer
Location:
11 B1.2; 11 28.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (48697230..48709026, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (48806403..48818199, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene receptor for activated C kinase 1 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene STARR-positive B cell enhancer ABC_E11476 Neighboring gene STARR-positive B cell enhancer ABC_E1822 Neighboring gene nuclear encoded tRNA valine 7 (anticodon CAC) Neighboring gene nuclear encoded tRNA glycine 1 (anticodon ACC)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC28280

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM41
Names
RING-type E3 ubiquitin transferase TRIM41
tripartite motif-containing protein 41
NP_663352.2
XP_006532821.1
XP_006532822.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145377.2NP_663352.2  E3 ubiquitin-protein ligase TRIM41

    See identical proteins and their annotated locations for NP_663352.2

    Status: VALIDATED

    Source sequence(s)
    AL645849, BC041780
    Consensus CDS
    CCDS36138.1
    UniProtKB/Swiss-Prot
    Q5NCC3
    Related
    ENSMUSP00000037055.8, ENSMUST00000047145.14
    Conserved Domains (5) summary
    cd00021
    Location:226263
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    cd13741
    Location:432630
    SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)
    pfam01442
    Location:263374
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cl00459
    Location:286381
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl17238
    Location:2048
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    48697230..48709026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532758.3XP_006532821.1  E3 ubiquitin-protein ligase TRIM41 isoform X1

    See identical proteins and their annotated locations for XP_006532821.1

    Conserved Domains (4) summary
    cd16602
    Location:1648
    RING-HC_TRIM41_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM41, TRIM52 and similar proteins
    pfam01442
    Location:263388
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    cd19762
    Location:225268
    Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins
    cl02614
    Location:432489
    SPRY; SPRY domain
  2. XM_006532759.5XP_006532822.1  E3 ubiquitin-protein ligase TRIM41 isoform X2

    See identical proteins and their annotated locations for XP_006532822.1

    Conserved Domains (2) summary
    cd13741
    Location:196394
    SPRY_PRY_TRIM41; PRY/SPRY domain in tripartite motif-binding protein 41 (TRIM41)
    pfam01442
    Location:33152
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RNA

  1. XR_004936899.1 RNA Sequence