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DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 [ Homo sapiens (human) ]

Gene ID: 9093, updated on 4-Feb-2024

Summary

Official Symbol
DNAJA3provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A3provided by HGNC
Primary source
HGNC:HGNC:11808
See related
Ensembl:ENSG00000103423 MIM:608382; AllianceGenome:HGNC:11808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TID1; HCA57; Tid1-L; Tid1-S; hTID-1
Summary
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in adrenal (RPKM 19.3), kidney (RPKM 17.5) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJA3 in Genome Data Viewer
Location:
16p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4425868..4456775)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4455068..4485978)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4475869..4506776)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CORO7-PAM16 readthrough Neighboring gene coronin 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4421231-4422056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4424664-4425443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4425537-4426318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4426319-4427098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4428659-4429440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4433428-4434269 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4440665-4441216 Neighboring gene vasorin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4441217-4441770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4452006-4452742 Neighboring gene uncharacterized LOC124903635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:4499977-4500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4505719-4506689 Neighboring gene MPRA-validated peak2472 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4516031-4516532 Neighboring gene NmrA like redox sensor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4526195-4526696 Neighboring gene uncharacterized LOC124903636 Neighboring gene heme oxygenase 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:4543888-4544077

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ45758

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
involved_in activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular senescence IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle acetylcholine-gated channel clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 3, mitochondrial
Names
DnaJ (Hsp40) homolog, subfamily A, member 3
dnaJ protein Tid-1
hepatocellular carcinoma-associated antigen 57
tumorous imaginal discs protein Tid56 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029866.1 RefSeqGene

    Range
    5064..35971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135110.3NP_001128582.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001128582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2, also known as TID1S) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK001333, BC020248, DA172592
    Consensus CDS
    CCDS45400.1
    UniProtKB/TrEMBL
    B3KM81
    Related
    ENSP00000347445.4, ENST00000355296.8
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90435
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain
  2. NM_001286516.2NP_001273445.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' end and an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC012676, AK001333, AK295391, BC011855, BX445320
    Consensus CDS
    CCDS66930.1
    UniProtKB/Swiss-Prot
    Q96EY1
    UniProtKB/TrEMBL
    B3KM81
    Related
    ENSP00000393970.2, ENST00000431375.6
    Conserved Domains (3) summary
    cd10719
    Location:83143
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:54263
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:37282
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  3. NM_005147.6NP_005138.3  dnaJ homolog subfamily A member 3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_005138.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as TID1L).
    Source sequence(s)
    AB209923, AK223105, BC011855
    Consensus CDS
    CCDS10515.1
    UniProtKB/Swiss-Prot
    B2RAJ5, B4DI33, E7ES32, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96EY1, Q96IV1, Q9NYH8
    UniProtKB/TrEMBL
    Q53G26, Q59E88
    Related
    ENSP00000262375.4, ENST00000262375.11
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90480
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4425868..4456775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434875.1XP_047290831.1  dnaJ homolog subfamily A member 3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B2RAJ5, B4DI33, E7ES32, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96EY1, Q96IV1, Q9NYH8
    UniProtKB/TrEMBL
    Q53G26, Q59E88

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    128191..159098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329188.1XP_054185163.1  dnaJ homolog subfamily A member 3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B2RAJ5, B4DI33, E7ES32, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96EY1, Q96IV1, Q9NYH8
    UniProtKB/TrEMBL
    Q53G26, Q59E88

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4455068..4485978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314330.1XP_054170305.1  dnaJ homolog subfamily A member 3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B2RAJ5, B4DI33, E7ES32, O75472, Q8WUJ6, Q8WXJ3, Q96D76, Q96EY1, Q96IV1, Q9NYH8
    UniProtKB/TrEMBL
    Q53G26, Q59E88