Format

Send to:

Choose Destination

DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 [ Homo sapiens (human) ]

Gene ID: 9093, updated on 9-Dec-2018

Summary

Official Symbol
DNAJA3provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member A3provided by HGNC
Primary source
HGNC:HGNC:11808
See related
Ensembl:ENSG00000103423 MIM:608382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TID1; HCA57; hTID-1
Summary
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in adrenal (RPKM 19.3), kidney (RPKM 17.5) and 25 other tissues See more
Orthologs

Genomic context

See DNAJA3 in Genome Data Viewer
Location:
16p13.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (4425805..4456775)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4475806..4506776)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CORO7-PAM16 readthrough Neighboring gene presequence translocase associated motor 16 Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene NmrA like redox sensor 1 Neighboring gene heme oxygenase 2 Neighboring gene cell death inducing p53 target 1 Neighboring gene chromosome 16 open reading frame 96

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45758

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
 
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
activation-induced cell death of T cells IEA
Inferred from Electronic Annotation
more info
 
cell aging IEA
Inferred from Electronic Annotation
more info
 
mitochondrial DNA replication IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle acetylcholine-gated channel clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 3, mitochondrial
Names
DnaJ (Hsp40) homolog, subfamily A, member 3
dnaJ protein Tid-1
hepatocellular carcinoma-associated antigen 57
tumorous imaginal discs protein Tid56 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029866.1 RefSeqGene

    Range
    5001..35971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135110.2NP_001128582.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001128582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2, also known as TID1S) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK001333, BC020248, BX445320, DA172592
    Consensus CDS
    CCDS45400.1
    UniProtKB/Swiss-Prot
    Q96EY1
    UniProtKB/TrEMBL
    B3KM81
    Related
    ENSP00000347445.4, ENST00000355296.8
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90435
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain
  2. NM_001286516.1NP_001273445.1  dnaJ homolog subfamily A member 3, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' end and an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC012676, AK001333, AK295391, BC011855, BX445320
    Consensus CDS
    CCDS66930.1
    UniProtKB/Swiss-Prot
    Q96EY1
    UniProtKB/TrEMBL
    B3KM81
    Related
    ENSP00000393970.2, ENST00000431375.6
    Conserved Domains (3) summary
    cd10719
    Location:83143
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:54263
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:37282
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  3. NM_005147.6NP_005138.3  dnaJ homolog subfamily A member 3, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_005138.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as TID1L).
    Source sequence(s)
    AB209923, AK223105, BC011855
    Consensus CDS
    CCDS10515.1
    UniProtKB/Swiss-Prot
    Q96EY1
    UniProtKB/TrEMBL
    Q53G26, Q59E88
    Related
    ENSP00000262375.4, ENST00000262375.10
    Conserved Domains (4) summary
    cd10719
    Location:236296
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:207416
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:90480
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:93155
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    4425805..4456775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187608.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    128128..159098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center