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SPOCD1 SPOC domain containing 1 [ Homo sapiens (human) ]

Gene ID: 90853, updated on 29-Sep-2020

Summary

Official Symbol
SPOCD1provided by HGNC
Official Full Name
SPOC domain containing 1provided by HGNC
Primary source
HGNC:HGNC:26338
See related
Ensembl:ENSG00000134668 MIM:619038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R146
Summary
This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Biased expression in testis (RPKM 4.6), urinary bladder (RPKM 3.3) and 7 other tissues See more
Orthologs

Genomic context

See SPOCD1 in Genome Data Viewer
Location:
1p35.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (31790422..31816051, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32256023..32281630, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11964 Neighboring gene adhesion G protein-coupled receptor B2 Neighboring gene microRNA 4254 Neighboring gene protein tyrosine phosphatase 4A2 Neighboring gene PTP4A2-KHDRBS1 intergenic CAGE-defined high expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25348, FLJ38873, FLJ39908

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SPOC domain-containing protein 1
Names
protein phosphatase 1, regulatory subunit 146

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281987.2NP_001268916.1  SPOC domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001268916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AL354919, BC114430, CA309202, DB084307
    Consensus CDS
    CCDS60066.1
    UniProtKB/Swiss-Prot
    Q6ZMY3
    Related
    ENSP00000435851.1, ENST00000533231.5
    Conserved Domains (2) summary
    pfam07500
    Location:608717
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:867965
    SPOC; SPOC domain
  2. NM_001281988.2NP_001268917.1  SPOC domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001268917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' terminal exon, lacks an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK091016, AL354919, CA309202, DB084307
    Consensus CDS
    CCDS72748.1
    UniProtKB/Swiss-Prot
    Q6ZMY3
    Related
    ENSP00000257100.3, ENST00000257100.7
    Conserved Domains (2) summary
    pfam07500
    Location:101210
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:360458
    SPOC; SPOC domain
  3. NM_144569.6NP_653170.3  SPOC domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_653170.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK131447, CA309202, DB084307
    Consensus CDS
    CCDS347.1
    UniProtKB/Swiss-Prot
    Q6ZMY3
    Related
    ENSP00000353670.2, ENST00000360482.6
    Conserved Domains (2) summary
    pfam07500
    Location:608717
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:867965
    SPOC; SPOC domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    31790422..31816051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542414.2XP_011540716.1  SPOC domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011540716.1

    UniProtKB/Swiss-Prot
    Q6ZMY3
    Conserved Domains (2) summary
    pfam07500
    Location:101210
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:360458
    SPOC; SPOC domain
  2. XM_011542413.2XP_011540715.1  SPOC domain-containing protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011540715.1

    UniProtKB/Swiss-Prot
    Q6ZMY3
    Conserved Domains (2) summary
    pfam07500
    Location:101210
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:360458
    SPOC; SPOC domain
  3. XM_017002782.1XP_016858271.1  SPOC domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    pfam07500
    Location:351460
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:610708
    SPOC; SPOC domain
  4. XM_017002780.1XP_016858269.1  SPOC domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    pfam07500
    Location:594703
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:853951
    SPOC; SPOC domain
  5. XM_017002781.1XP_016858270.1  SPOC domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    pfam07500
    Location:608715
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:825923
    SPOC; SPOC domain
  6. XM_017002779.1XP_016858268.1  SPOC domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07500
    Location:608717
    TFIIS_M; Transcription factor S-II (TFIIS), central domain
    pfam07744
    Location:866964
    SPOC; SPOC domain

RNA

  1. XR_001737533.1 RNA Sequence

  2. XR_946797.2 RNA Sequence

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