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VCY variable charge Y-linked [ Homo sapiens (human) ]

Gene ID: 9084, updated on 5-Jan-2022

Summary

Official Symbol
VCYprovided by HGNC
Official Full Name
variable charge Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:12668
See related
Ensembl:ENSG00000129864 MIM:400012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BPY1; VCY1; VCY1A
Summary
The protein encoded by this gene is a member of a family of human VCX/Y genes. This gene family has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. Members of the VCX/Y family share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. VCX/Y genes encode small and highly charged proteins of unknown function. This gene encodes a small, positively charged protein. The presence of a putative bipartite nuclear localization signal suggests that this gene encodes a nuclear protein. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 20.6) See more
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Genomic context

See VCY in Genome Data Viewer
Location:
Yq11.221
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (13985772..13986473, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (16097652..16098393, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene PC4 and SFRS1 interacting protein 1 pseudogene 2 Neighboring gene anosmin 2, pseudogene Neighboring gene variable charge Y-linked 1B Neighboring gene patatin like phospholipase domain containing 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC119817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
testis-specific basic protein Y 1
Names
basic charge, Y-linked 1
basic protein on Y chromosome, 1
testis-specific basic protein on Y, 1
variable charge, Y chromosome
variably charged protein Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032915.1 RefSeqGene

    Range
    5001..5741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004679.4NP_004670.1  testis-specific basic protein Y 1

    See identical proteins and their annotated locations for NP_004670.1

    Status: REVIEWED

    Source sequence(s)
    AF000979, AI149997
    Consensus CDS
    CCDS56617.1
    UniProtKB/Swiss-Prot
    O14598
    Related
    ENSP00000250825.4, ENST00000250825.5
    Conserved Domains (1) summary
    pfam15231
    Location:1116
    VCX_VCY; Variable charge X/Y family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    13985772..13986473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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