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CLDN6 claudin 6 [ Homo sapiens (human) ]

Gene ID: 9074, updated on 20-Sep-2020


Official Symbol
CLDN6provided by HGNC
Official Full Name
claudin 6provided by HGNC
Primary source
See related
Ensembl:ENSG00000184697 MIM:615798
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Low expression observed in reference dataset See more

Genomic context

See CLDN6 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3014712..3018183, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3064713..3068188, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984895 Neighboring gene uncharacterized LOC105371056 Neighboring gene claudin 9 Neighboring gene TNF receptor superfamily member 12A Neighboring gene host cell factor C1 regulator 1 Neighboring gene THO complex 6

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of claudin 6 (CLDN6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
protein binding IPI
Inferred from Physical Interaction
more info
structural molecule activity IEA
Inferred from Electronic Annotation
more info
virus receptor activity IMP
Inferred from Mutant Phenotype
more info
Process Evidence Code Pubs
bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
apicolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
integral component of membrane IEA
Inferred from Electronic Annotation
more info
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
plasma membrane IDA
Inferred from Direct Assay
more info

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021195.5NP_067018.2  claudin-6 precursor

    See identical proteins and their annotated locations for NP_067018.2

    Status: REVIEWED

    Source sequence(s)
    BC008934, BX444798, CN420342
    Consensus CDS
    ENSP00000328674.4, ENST00000328796.5
    Conserved Domains (1) summary
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    3014712..3018183 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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