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STARD13 StAR related lipid transfer domain containing 13 [ Homo sapiens (human) ]

Gene ID: 90627, updated on 7-Dec-2018

Summary

Official Symbol
STARD13provided by HGNC
Official Full Name
StAR related lipid transfer domain containing 13provided by HGNC
Primary source
HGNC:HGNC:19164
See related
Ensembl:ENSG00000133121 MIM:609866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLC2; GT650; ARHGAP37; LINC00464
Summary
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in placenta (RPKM 9.3), thyroid (RPKM 7.8) and 24 other tissues See more
Orthologs

Genomic context

See STARD13 in Genome Data Viewer
Location:
13q13.1-q13.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (33103135..33676835, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (33677272..34250932, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene TOMM22 pseudogene 3 Neighboring gene klotho Neighboring gene STARD13 antisense RNA Neighboring gene uncharacterized LOC112268116 Neighboring gene long intergenic non-protein coding RNA 2344 Neighboring gene uncharacterized LOC102723406 Neighboring gene uncharacterized LOC107984551 Neighboring gene RNA, U5A small nuclear 4, pseudogene Neighboring gene replication factor C subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
NHGRI GWA Catalog
A genome-wide association study of behavioral disinhibition.
NHGRI GWA Catalog
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
NHGRI GWA Catalog
Genome-wide association study of intracranial aneurysm identifies three new risk loci.
NHGRI GWA Catalog

Pathways from BioSystems

  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity TAS
Traceable Author Statement
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial tube lumen extension IGI
Inferred from Genetic Interaction
more info
PubMed 
endothelial tube lumen extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stAR-related lipid transfer protein 13
Names
Rho GTPase activating protein on chromosome 13q12
StAR-related lipid transfer (START) domain containing 13
deleted in liver cancer 2 protein
long intergenic non-protein coding RNA 464

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029752.2 RefSeqGene

    Range
    396072..578701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243466.1NP_001230395.1  stAR-related lipid transfer protein 13 isoform 5

    See identical proteins and their annotated locations for NP_001230395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in a shorter isoform (5) with distinct N- and C- termini compared to isoform 1.
    Source sequence(s)
    AK308453, BC046563
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Conserved Domains (2) summary
    cd09592
    Location:49112
    SAM_DLC2; SAM domain of STARD13-like subfamily
    cl02570
    Location:649686
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  2. NM_001243474.1NP_001230403.1  stAR-related lipid transfer protein 13 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (6) with a shorter N-terminus, and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK091804, AK308453, BC046563, BP233049
    UniProtKB/Swiss-Prot
    Q9Y3M8
    UniProtKB/TrEMBL
    B3KRK6
    Conserved Domains (1) summary
    cl02570
    Location:539642
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  3. NM_001243476.2NP_001230405.1  stAR-related lipid transfer protein 13 isoform 4

    See identical proteins and their annotated locations for NP_001230405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' coding region and contains multiple alternate 5' exons, and initiates initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (4) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA256386, AK308453, AY082589, BX647695, CB163673, DA312208, DB449764
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Conserved Domains (3) summary
    cd08909
    Location:8651069
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:2285
    SAM_DLC2; SAM domain of STARD13-like subfamily
    cd04375
    Location:622839
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  4. NM_052851.2NP_443083.1  stAR-related lipid transfer protein 13 isoform 3

    See identical proteins and their annotated locations for NP_443083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as DLC2gamma) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA256386, AL049801, AY082590, AY082591, AY366448, BP233049, CB163673
    Consensus CDS
    CCDS9350.1
    UniProtKB/Swiss-Prot
    Q9Y3M8
    UniProtKB/TrEMBL
    B2R789
    Related
    ENSP00000382300.3, ENST00000399365.7
    Conserved Domains (2) summary
    cd08909
    Location:782986
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd04375
    Location:539756
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  5. NM_178006.4NP_821074.1  stAR-related lipid transfer protein 13 isoform 1

    See identical proteins and their annotated locations for NP_821074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as DLC2alpha).
    Source sequence(s)
    AA256386, AY082589, AY082590, AY366448, CB163673, DC402824
    Consensus CDS
    CCDS9348.1
    UniProtKB/Swiss-Prot
    Q9Y3M8
    UniProtKB/TrEMBL
    A0A024RDV4
    Related
    ENSP00000338785.4, ENST00000336934.9
    Conserved Domains (4) summary
    cd08909
    Location:9001104
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:57120
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:61120
    SAM; Sterile alpha motif
    cd04375
    Location:657874
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  6. NM_178007.2NP_821075.1  stAR-related lipid transfer protein 13 isoform 2

    See identical proteins and their annotated locations for NP_821075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (2, also known as DLC2beta) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA256386, AY082590, AY366448, CB163673
    Consensus CDS
    CCDS9349.1
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Related
    ENSP00000255486.4, ENST00000255486.8
    Conserved Domains (4) summary
    cd08909
    Location:8921096
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:49112
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:53112
    SAM; Sterile alpha motif
    cd04375
    Location:649866
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    33103135..33676835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020835.2XP_016876324.1  stAR-related lipid transfer protein 13 isoform X2

    Conserved Domains (3) summary
    cd08909
    Location:8651069
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:2285
    SAM_DLC2; SAM domain of STARD13-like subfamily
    cd04375
    Location:622839
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  2. XM_011535299.3XP_011533601.1  stAR-related lipid transfer protein 13 isoform X2

    See identical proteins and their annotated locations for XP_011533601.1

    Conserved Domains (3) summary
    cd08909
    Location:8651069
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:2285
    SAM_DLC2; SAM domain of STARD13-like subfamily
    cd04375
    Location:622839
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  3. XM_024449429.1XP_024305197.1  stAR-related lipid transfer protein 13 isoform X2

    Conserved Domains (3) summary
    cd08909
    Location:8651069
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:2285
    SAM_DLC2; SAM domain of STARD13-like subfamily
    cd04375
    Location:622839
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  4. XM_017020834.2XP_016876323.1  stAR-related lipid transfer protein 13 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178008.1: Suppressed sequence

    Description
    NM_178008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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