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Stard13 StAR related lipid transfer domain containing 13 [ Mus musculus (house mouse) ]

Gene ID: 243362, updated on 8-Feb-2024

Summary

Official Symbol
Stard13provided by MGI
Official Full Name
StAR related lipid transfer domain containing 13provided by MGI
Primary source
MGI:MGI:2385331
See related
Ensembl:ENSMUSG00000016128 AllianceGenome:MGI:2385331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DLC2; GT650
Summary
Predicted to enable GTPase activator activity. Acts upstream of or within negative regulation of sprouting angiogenesis. Predicted to be located in lipid droplet; membrane; and mitochondrion. Orthologous to human STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 12.8), bladder adult (RPKM 6.2) and 23 other tissues See more
Orthologs
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Genomic context

See Stard13 in Genome Data Viewer
Location:
5 G3; 5 89.82 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150960975..151351780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (151037515..151428200, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene klotho Neighboring gene predicted gene 8675 Neighboring gene STARR-seq mESC enhancer starr_14970 Neighboring gene STARR-seq mESC enhancer starr_14971 Neighboring gene RIKEN cDNA 5430435K18 gene Neighboring gene predicted gene, 52834 Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene RIKEN cDNA 1700028E10 gene Neighboring gene STARR-seq mESC enhancer starr_14974 Neighboring gene STARR-seq mESC enhancer starr_14976 Neighboring gene vomeronasal 2, receptor, pseudogene 25 Neighboring gene predicted gene 3704 Neighboring gene vomeronasal 2, receptor, pseudogene 26

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC38133

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stAR-related lipid transfer protein 13
Names
START domain-containing protein 13
StAR-related lipid transfer (START) domain containing 13
serologically defined colon cancer antigen 13
serologically defined colon cancer antigen 28

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163493.2NP_001156965.1  stAR-related lipid transfer protein 13 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC109614, AC163219
    Consensus CDS
    CCDS51710.1
    UniProtKB/TrEMBL
    A0A2X0SFI9, F8WIY7
    Related
    ENSMUSP00000053232.9, ENSMUST00000062015.15
    Conserved Domains (4) summary
    cd09592
    Location:57120
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:61120
    SAM; Sterile alpha motif
    cd04375
    Location:676893
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:9201123
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. NM_001359985.2NP_001346914.1  stAR-related lipid transfer protein 13 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A2X0SFI9
    Conserved Domains (2) summary
    cd04375
    Location:481698
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:725928
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. NM_001424723.1NP_001411652.1  stAR-related lipid transfer protein 13 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A2X0SFI9
  4. NM_001424724.1NP_001411653.1  stAR-related lipid transfer protein 13 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A2X0SFI9
  5. NM_001424725.1NP_001411654.1  stAR-related lipid transfer protein 13 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A0J9YU82, A0A2X0SFI9
  6. NM_001424726.1NP_001411655.1  stAR-related lipid transfer protein 13 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A0J9YU82, A0A2X0SFI9
  7. NM_001424727.1NP_001411656.1  stAR-related lipid transfer protein 13 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A2X0SFI9
  8. NM_001424728.1NP_001411657.1  stAR-related lipid transfer protein 13 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC109614, AC163219
    UniProtKB/TrEMBL
    A0A2X0SFI9
  9. NM_146258.3NP_666370.3  stAR-related lipid transfer protein 13 isoform 2

    See identical proteins and their annotated locations for NP_666370.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a protein (isoform 2) that is 19 amino acids shorter than isoform 1.
    Source sequence(s)
    AC109614, AC163219
    Consensus CDS
    CCDS19890.1
    UniProtKB/Swiss-Prot
    E9PUB5, Q8K369, Q923Q2
    UniProtKB/TrEMBL
    A0A2X0SFI9
    Related
    ENSMUSP00000106109.3, ENSMUST00000110483.9
    Conserved Domains (4) summary
    cd09592
    Location:57120
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:61120
    SAM; Sterile alpha motif
    cd04375
    Location:657874
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
    cl14643
    Location:9011104
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RNA

  1. NR_153382.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC109614, AC163219

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    150960975..151351780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504923.5XP_006504986.1  stAR-related lipid transfer protein 13 isoform X3

    See identical proteins and their annotated locations for XP_006504986.1

    UniProtKB/TrEMBL
    A0A2X0SFI9
    Conserved Domains (2) summary
    cd04375
    Location:558775
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:8021005
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  2. XM_006504918.5XP_006504981.1  stAR-related lipid transfer protein 13 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SFI9
    Conserved Domains (3) summary
    cd09592
    Location:42105
    SAM_DLC2; SAM domain of STARD13-like subfamily
    cd04375
    Location:661878
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:9051108
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  3. XM_006504921.3XP_006504984.1  stAR-related lipid transfer protein 13 isoform X3

    See identical proteins and their annotated locations for XP_006504984.1

    UniProtKB/TrEMBL
    A0A2X0SFI9
    Conserved Domains (2) summary
    cd04375
    Location:558775
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:8021005
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  4. XM_036165136.1XP_036021029.1  stAR-related lipid transfer protein 13 isoform X5

    UniProtKB/TrEMBL
    A0A0J9YU82, A0A2X0SFI9
    Conserved Domains (2) summary
    cd04375
    Location:539756
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:783986
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  5. XM_006504922.5XP_006504985.1  stAR-related lipid transfer protein 13 isoform X3

    See identical proteins and their annotated locations for XP_006504985.1

    UniProtKB/TrEMBL
    A0A2X0SFI9
    Conserved Domains (2) summary
    cd04375
    Location:558775
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:8021005
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
  6. XM_036165133.1XP_036021026.1  stAR-related lipid transfer protein 13 isoform X4

    UniProtKB/TrEMBL
    A0A2X0SFI9
    Conserved Domains (2) summary
    cd04375
    Location:550767
    RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...
    cl14643
    Location:794997
    SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RNA

  1. XR_004942515.1 RNA Sequence