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SHF Src homology 2 domain containing F [ Homo sapiens (human) ]

Gene ID: 90525, updated on 12-Aug-2022

Summary

Official Symbol
SHFprovided by HGNC
Official Full Name
Src homology 2 domain containing Fprovided by HGNC
Primary source
HGNC:HGNC:25116
See related
Ensembl:ENSG00000138606 MIM:617313; AllianceGenome:HGNC:25116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 4.2), ovary (RPKM 4.0) and 23 other tissues See more
Orthologs
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Genomic context

See SHF in Genome Data Viewer
Location:
15q21.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (45167214..45201116, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (42975223..43009099, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45459412..45493314, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene uncharacterized LOC124903480 Neighboring gene uncharacterized LOC124903481 Neighboring gene tRNA-His (anticodon GTG) 1-7 Neighboring gene tRNA-His (anticodon GTG) 1-8 Neighboring gene tRNA-His (anticodon GTG) 1-9 Neighboring gene small nucleolar RNA SNORA11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126650, MGC126652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH2 domain-containing adapter protein F
Names
CTD-2651B20.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301168.2NP_001288097.2  SH2 domain-containing adapter protein F isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC051619
    Conserved Domains (1) summary
    cd10392
    Location:339436
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  2. NM_001301169.2NP_001288098.2  SH2 domain-containing adapter protein F isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS76750.1
    UniProtKB/TrEMBL
    H0YLW6
    Related
    ENSP00000453370.1, ENST00000560540.5
  3. NM_001301170.2NP_001288099.2  SH2 domain-containing adapter protein F isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS76749.1
    UniProtKB/TrEMBL
    H0YLD8
    Related
    ENSP00000453168.1, ENST00000560734.5
  4. NM_001301171.2NP_001288100.2  SH2 domain-containing adapter protein F isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS73721.1
    UniProtKB/TrEMBL
    F8W6V4
    Related
    ENSP00000411530.2, ENST00000458022.6
    Conserved Domains (1) summary
    cd10392
    Location:137234
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  5. NM_001394037.1NP_001380966.1  SH2 domain-containing adapter protein F isoform f

    Status: VALIDATED

    Source sequence(s)
    AC051619
    Related
    ENSP00000508579.1, ENST00000690270.1
    Conserved Domains (1) summary
    cd10392
    Location:386483
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  6. NM_001394038.1NP_001380967.1  SH2 domain-containing adapter protein F isoform g

    Status: VALIDATED

    Source sequence(s)
    AC051619
    UniProtKB/TrEMBL
    H0YLM1
    Related
    ENSP00000453260.1, ENST00000560471.5
  7. NM_001394039.1NP_001380968.1  SH2 domain-containing adapter protein F isoform h

    Status: VALIDATED

    Source sequence(s)
    AC051619
    Conserved Domains (1) summary
    cd10392
    Location:309404
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  8. NM_001394040.1NP_001380969.1  SH2 domain-containing adapter protein F isoform i

    Status: VALIDATED

    Source sequence(s)
    AC051619
  9. NM_001394041.1NP_001380970.1  SH2 domain-containing adapter protein F isoform j

    Status: VALIDATED

    Source sequence(s)
    AC051619
    Conserved Domains (1) summary
    PHA03247
    Location:145345
    PHA03247; large tegument protein UL36; Provisional
  10. NM_001394042.1NP_001380971.1  SH2 domain-containing adapter protein F isoform k

    Status: VALIDATED

    Source sequence(s)
    AC051619
  11. NM_001394043.1NP_001380972.1  SH2 domain-containing adapter protein F isoform l

    Status: VALIDATED

    Source sequence(s)
    AC051619
  12. NM_001394044.1NP_001380973.1  SH2 domain-containing adapter protein F isoform m

    Status: VALIDATED

    Source sequence(s)
    AC051619
  13. NM_001394045.1NP_001380974.1  SH2 domain-containing adapter protein F isoform n

    Status: VALIDATED

    Source sequence(s)
    AC051619
  14. NM_001394046.1NP_001380975.1  SH2 domain-containing adapter protein F isoform o

    Status: VALIDATED

    Source sequence(s)
    AC051619
  15. NM_001394047.1NP_001380976.1  SH2 domain-containing adapter protein F isoform p

    Status: VALIDATED

    Source sequence(s)
    AC051619
  16. NM_001394048.1NP_001380977.1  SH2 domain-containing adapter protein F isoform q

    Status: VALIDATED

    Source sequence(s)
    AC051619
  17. NM_138356.3NP_612365.3  SH2 domain-containing adapter protein F isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it includes an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS10120.2
    UniProtKB/Swiss-Prot
    Q96IE8
    Related
    ENSP00000290894.8, ENST00000290894.12
    Conserved Domains (2) summary
    cd10392
    Location:321418
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
    PHA03247
    Location:145317
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    45167214..45201116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433286.1XP_047289242.1  SH2 domain-containing adapter protein F isoform X3

  2. XM_047433285.1XP_047289241.1  SH2 domain-containing adapter protein F isoform X2

  3. XM_017022710.2XP_016878199.1  SH2 domain-containing adapter protein F isoform X4

  4. XM_011522178.3XP_011520480.1  SH2 domain-containing adapter protein F isoform X5

  5. XM_047433284.1XP_047289240.1  SH2 domain-containing adapter protein F isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    42975223..43009099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)