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SHF Src homology 2 domain containing F [ Homo sapiens (human) ]

Gene ID: 90525, updated on 5-Sep-2020

Summary

Official Symbol
SHFprovided by HGNC
Official Full Name
Src homology 2 domain containing Fprovided by HGNC
Primary source
HGNC:HGNC:25116
See related
Ensembl:ENSG00000138606 MIM:617313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in adrenal (RPKM 4.2), ovary (RPKM 4.0) and 23 other tissues See more
Orthologs

Genomic context

See SHF in Genome Data Viewer
Location:
15q21.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (45167214..45201116, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45459412..45493373, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene tRNA-His (anticodon GTG) 1-7 Neighboring gene tRNA-His (anticodon GTG) 1-8 Neighboring gene tRNA-His (anticodon GTG) 1-9 Neighboring gene H3 histone pseudogene 39

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126650, MGC126652

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH2 domain-containing adapter protein F
Names
CTD-2651B20.7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301168.2NP_001288097.2  SH2 domain-containing adapter protein F isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC051619
    Conserved Domains (1) summary
    cd10392
    Location:339436
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  2. NM_001301169.2NP_001288098.2  SH2 domain-containing adapter protein F isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS76750.1
    Related
    ENSP00000453370.1, ENST00000560540.5
  3. NM_001301170.2NP_001288099.2  SH2 domain-containing adapter protein F isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS76749.1
    Related
    ENSP00000453168.1, ENST00000560734.5
  4. NM_001301171.2NP_001288100.2  SH2 domain-containing adapter protein F isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure and it thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS73721.1
    Related
    ENSP00000411530.2, ENST00000458022.6
  5. NM_138356.3NP_612365.3  SH2 domain-containing adapter protein F isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it includes an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC051619
    Consensus CDS
    CCDS10120.2
    Related
    ENSP00000290894.8, ENST00000290894.12

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    45167214..45201116 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022710.1XP_016878199.1  SH2 domain-containing adapter protein F isoform X4

  2. XM_011522177.2XP_011520479.1  SH2 domain-containing adapter protein F isoform X5

  3. XM_011522176.2XP_011520478.1  SH2 domain-containing adapter protein F isoform X3

    Conserved Domains (1) summary
    cd10392
    Location:309404
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  4. XM_006720742.3XP_006720805.2  SH2 domain-containing adapter protein F isoform X2

    See identical proteins and their annotated locations for XP_006720805.2

    UniProtKB/TrEMBL
    H0YLM1
  5. XM_017022711.2XP_016878200.1  SH2 domain-containing adapter protein F isoform X7

    Conserved Domains (1) summary
    cd10392
    Location:184281
    SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
  6. XM_011522178.2XP_011520480.1  SH2 domain-containing adapter protein F isoform X6

  7. XM_011522175.2XP_011520477.1  SH2 domain-containing adapter protein F isoform X2

    See identical proteins and their annotated locations for XP_011520477.1

    UniProtKB/TrEMBL
    H0YLM1
    Related
    ENSP00000453260.1, ENST00000560471.5
  8. XM_011522174.2XP_011520476.1  SH2 domain-containing adapter protein F isoform X1

    Conserved Domains (1) summary
    cl15255
    Location:386427
    SH2; Src homology 2 (SH2) domain
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