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GPRC5A G protein-coupled receptor class C group 5 member A [ Homo sapiens (human) ]

Gene ID: 9052, updated on 17-Jun-2018
Official Symbol
GPRC5Aprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Aprovided by HGNC
Primary source
HGNC:HGNC:9836
See related
Ensembl:ENSG00000013588 MIM:604138; Vega:OTTHUMG00000168710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI3; TIG1; RAIG1; GPCR5A; PEIG-1
Summary
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues See more
Orthologs
See GPRC5A in Genome Data Viewer
Location:
12p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (12891022..12913666)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13043956..13066600)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene ribosomal protein L13a pseudogene 20 Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene G protein-coupled receptor class C group 5 member D

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem (from WikiPathways)
    GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
retinoic acid-induced protein 3
Names
G-protein coupled receptor family C group 5 member A
TPA induced gene 1
orphan G-protein-coupling receptor PEIG-1
phorbol ester induced gene 1
phorbol ester induced protein-1
retinoic acid induced 3
retinoic acid responsive
retinoic acid-induced gene 1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003979.3NP_003970.1  retinoic acid-induced protein 3

    See identical proteins and their annotated locations for NP_003970.1

    Status: REVIEWED

    Source sequence(s)
    AF095448, AI587426, AK122672
    Consensus CDS
    CCDS8657.1
    UniProtKB/Swiss-Prot
    Q8NFJ5
    Related
    ENSP00000014914.5, OTTHUMP00000239229, ENST00000014914.5, OTTHUMT00000400682
    Conserved Domains (1) summary
    pfam00003
    Location:66267
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    12891022..12913666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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