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GPRC5A G protein-coupled receptor class C group 5 member A [ Homo sapiens (human) ]

Gene ID: 9052, updated on 13-Mar-2020

Summary

Official Symbol
GPRC5Aprovided by HGNC
Official Full Name
G protein-coupled receptor class C group 5 member Aprovided by HGNC
Primary source
HGNC:HGNC:9836
See related
Ensembl:ENSG00000013588 MIM:604138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI3; TIG1; RAIG1; GPCR5A; PEIG-1
Summary
This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung (RPKM 125.2), colon (RPKM 33.4) and 9 other tissues See more
Orthologs

Genomic context

See GPRC5A in Genome Data Viewer
Location:
12p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (12891562..12917937)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13043956..13066600)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene ribosomal protein L13a pseudogene 20 Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene G protein-coupled receptor class C group 5 member D Neighboring gene heme binding protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
retinoic acid-induced protein 3
Names
G-protein coupled receptor family C group 5 member A
TPA induced gene 1
orphan G-protein-coupling receptor PEIG-1
phorbol ester induced gene 1
phorbol ester induced protein-1
retinoic acid induced 3
retinoic acid responsive
retinoic acid-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003979.4NP_003970.1  retinoic acid-induced protein 3

    See identical proteins and their annotated locations for NP_003970.1

    Status: REVIEWED

    Source sequence(s)
    AC007688, AF095448, AI587426, AK122672
    Consensus CDS
    CCDS8657.1
    UniProtKB/Swiss-Prot
    Q8NFJ5
    Related
    ENSP00000014914.5, ENST00000014914.5
    Conserved Domains (1) summary
    pfam00003
    Location:66267
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12891562..12917937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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