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Gprc5a G protein-coupled receptor, family C, group 5, member A [ Mus musculus (house mouse) ]

Gene ID: 232431, updated on 5-Mar-2024

Summary

Official Symbol
Gprc5aprovided by MGI
Official Full Name
G protein-coupled receptor, family C, group 5, member Aprovided by MGI
Primary source
MGI:MGI:1891250
See related
Ensembl:ENSMUSG00000046733 AllianceGenome:MGI:1891250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rai3; Raig1
Summary
Predicted to enable protein kinase activator activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in plasma membrane. Is expressed in alimentary system; nose; respiratory system; and urinary system. Orthologous to human GPRC5A (G protein-coupled receptor class C group 5 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 130.8), colon adult (RPKM 45.8) and 4 other tissues See more
Orthologs
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Genomic context

See Gprc5a in Genome Data Viewer
Location:
6 G1; 6 65.83 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135042660..135061707)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135065662..135084709)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36428 Neighboring gene apolipoprotein L domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E865 Neighboring gene DEAD box helicase 47 Neighboring gene STARR-seq mESC enhancer starr_17562 Neighboring gene G protein-coupled receptor, family C, group 5, member D Neighboring gene Hebp1R1 erythroid cis-regulatory module Neighboring gene fucose mutarotase-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
retinoic acid-induced protein 3
Names
RAIG-1
retinoic acid induced 3
retinoic acid-induced gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181444.5NP_852109.2  retinoic acid-induced protein 3

    See identical proteins and their annotated locations for NP_852109.2

    Status: VALIDATED

    Source sequence(s)
    AC131718
    Consensus CDS
    CCDS20644.1
    UniProtKB/Swiss-Prot
    Q8BHL4, Q8K067, Q8K1G5
    UniProtKB/TrEMBL
    G5E8C3
    Related
    ENSMUSP00000061062.8, ENSMUST00000050104.8
    Conserved Domains (1) summary
    cd15279
    Location:28272
    7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135042660..135061707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506038.3XP_006506101.1  retinoic acid-induced protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006506101.1

    UniProtKB/Swiss-Prot
    Q8BHL4, Q8K067, Q8K1G5
    UniProtKB/TrEMBL
    G5E8C3
    Conserved Domains (1) summary
    cd15279
    Location:28272
    7tmC_RAIG1_4_GPRC5A_D; retinoic acid-inducible orphan G-protein-coupled receptors 1 and 4; class C family of seven-transmembrane G protein-coupled receptors, group 5, member A and D