Format

Send to:

Choose Destination

CCNT2 cyclin T2 [ Homo sapiens (human) ]

Gene ID: 905, updated on 6-Jan-2019

Summary

Official Symbol
CCNT2provided by HGNC
Official Full Name
cyclin T2provided by HGNC
Primary source
HGNC:HGNC:1600
See related
Ensembl:ENSG00000082258 MIM:603862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYCT2
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See CCNT2 in Genome Data Viewer
Location:
2q21.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (134918810..134959345)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135676363..135716915)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene CCNT2 antisense RNA 1 Neighboring gene microRNA 5590 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene HNF4 motif-containing MPRA enhancer 203

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclin T2 competes with cyclin T1 for binding to CDK9 and can thereby inhibit HIV-1 Tat activity PubMed
tat Amino acids 260-263 of cyclin T1 are critical for HIV-1 Tat-mediated transcriptional activation, and site-directed mutations in this region of cyclin T2 (asparagine to cysteine at residue 260) allow it to bind Tat and stimulate transcription PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13583, FLJ90560, MGC134840

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7SK snRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
transcription coactivator binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclin/CDK positive transcription elongation factor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cyclin-T2
Names
SDS-stable vimentin-bound DNA fragment HEF42VIM22
cyclin T2a
cyclin T2b
subunit of positive elongation transcription factor b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029189.1 RefSeqGene

    Range
    5001..45524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001241.3NP_001232.1  cyclin-T2 isoform a

    See identical proteins and their annotated locations for NP_001232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes isoform a.
    Source sequence(s)
    AC016725, AK294889, AU157699, BC114366
    Consensus CDS
    CCDS2175.1
    UniProtKB/Swiss-Prot
    O60583
    UniProtKB/TrEMBL
    B4DH21
    Related
    ENSP00000295238.6, ENST00000295238.10
    Conserved Domains (2) summary
    COG5333
    Location:8216
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
    cd00043
    Location:37108
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. NM_001320748.1NP_001307677.1  cyclin-T2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) contains an alternate internal exon and an alternate internal segment in the 3' end compared to variant a. The resulting isoform (d) has a shorter and distinct N-terminus and a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC016725, AK294889, BI769278
    UniProtKB/TrEMBL
    B4DH21
    Conserved Domains (1) summary
    cl02571
    Location:152283
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  3. NM_001320749.1NP_001307678.1  cyclin-T2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) contains an alternate internal exon and an alternate internal segment in the 3' end compared to variant a. The resulting isoform (e) is shorter at the N-terminus and has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC016725, AK294889
    UniProtKB/TrEMBL
    B4DH21
    Conserved Domains (1) summary
    COG5422
    Location:121252
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
  4. NM_058241.3NP_490595.1  cyclin-T2 isoform b

    See identical proteins and their annotated locations for NP_490595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) contains an additional internal fragment in the 3' coding region, which results in a frameshift, compared to variant a. The resulting isoform (b) is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC016725, AK292913, AK294889
    Consensus CDS
    CCDS2174.1
    UniProtKB/Swiss-Prot
    O60583
    UniProtKB/TrEMBL
    B4DH21
    Related
    ENSP00000264157.5, ENST00000264157.9
    Conserved Domains (2) summary
    COG5333
    Location:8216
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
    cd00043
    Location:37108
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RNA

  1. NR_037649.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) has an addition exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016725, AK294889
  2. NR_135468.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) contains an alternate exon, uses an alternate splice junction, and contains an alternate segment in the 3' end compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC016725, BX648174

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    134918810..134959345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005227.1XP_016860716.1  cyclin-T2 isoform X1

  2. XM_017005232.2XP_016860721.1  cyclin-T2 isoform X6

    UniProtKB/TrEMBL
    B4DH21
    Conserved Domains (1) summary
    cl02571
    Location:121252
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  3. XM_017005230.1XP_016860719.1  cyclin-T2 isoform X4

    Conserved Domains (1) summary
    COG5422
    Location:121252
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
  4. XM_017005231.2XP_016860720.1  cyclin-T2 isoform X5

  5. XM_017005229.1XP_016860718.1  cyclin-T2 isoform X3

    Conserved Domains (1) summary
    cl02571
    Location:152283
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  6. XM_017005228.2XP_016860717.1  cyclin-T2 isoform X2

  7. XM_024453212.1XP_024308980.1  cyclin-T2 isoform X6

    Conserved Domains (1) summary
    cl02571
    Location:121252
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  8. XM_024453211.1XP_024308979.1  cyclin-T2 isoform X3

    Conserved Domains (1) summary
    cl02571
    Location:152283
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
  9. XM_024453213.1XP_024308981.1  cyclin-T2 isoform X7

  10. XM_017005233.2XP_016860722.1  cyclin-T2 isoform X7

  11. XM_024453214.1XP_024308982.1  cyclin-T2 isoform X7

RNA

  1. XR_001739026.1 RNA Sequence

  2. XR_001739027.1 RNA Sequence

Support Center