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SH2D2A SH2 domain containing 2A [ Homo sapiens (human) ]

Gene ID: 9047, updated on 13-Feb-2019

Summary

Official Symbol
SH2D2Aprovided by HGNC
Official Full Name
SH2 domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:10821
See related
Ensembl:ENSG00000027869 MIM:604514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCAP; TSAD; VRAP; F2771
Summary
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression
Broad expression in appendix (RPKM 5.2), lymph node (RPKM 3.5) and 17 other tissues See more
Orthologs

Genomic context

See SH2D2A in Genome Data Viewer
Location:
1q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156806238..156816853, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156776035..156786640, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene heparin binding growth factor Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene insulin receptor related receptor Neighboring gene platelet endothelial aggregation receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
    ErbB1 downstream signaling, organism-specific biosystem
    ErbB1 downstream signaling
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • VEGF signaling pathway, organism-specific biosystem (from KEGG)
    VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGF signaling pathway, conserved biosystem (from KEGG)
    VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
SH3/SH2 adaptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SH2 domain-containing protein 2A
Names
SH2 domain protein 2A
T cell specific adapter protein TSAd
T lymphocyte specific adaptor protein
VEGF receptor-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016849.1 RefSeqGene

    Range
    5001..15606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161441.1NP_001154913.1  SH2 domain-containing protein 2A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL158169, AY763099, BQ012931, DB128222
    Consensus CDS
    CCDS53381.1
    UniProtKB/TrEMBL
    Q5UBZ2
    Related
    ENSP00000376123.2, ENST00000392306.2
    Conserved Domains (1) summary
    cl15255
    Location:87198
    SH2; Src homology 2 (SH2) domain
  2. NM_001161442.1NP_001154914.1  SH2 domain-containing protein 2A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF051325, AL158169, DB128222
    Consensus CDS
    CCDS53380.1
    UniProtKB/Swiss-Prot
    Q9NP31
    Related
    ENSP00000357181.3, ENST00000368198.7
    Conserved Domains (1) summary
    cd10416
    Location:69170
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  3. NM_001161443.1NP_001154915.1  SH2 domain-containing protein 2A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL158169, AY763098, BQ012931
    UniProtKB/TrEMBL
    Q5UBZ3
    Conserved Domains (1) summary
    cd10416
    Location:59160
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  4. NM_001161444.1NP_001154916.1  SH2 domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_001154916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR, and coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AK222737, DB128222
    Consensus CDS
    CCDS1159.1
    UniProtKB/Swiss-Prot
    Q9NP31
    Conserved Domains (1) summary
    cd10416
    Location:87188
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  5. NM_003975.3NP_003966.2  SH2 domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_003966.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AL158169, BC012107, DB128222
    Consensus CDS
    CCDS1159.1
    UniProtKB/Swiss-Prot
    Q9NP31
    Related
    ENSP00000357182.3, ENST00000368199.7
    Conserved Domains (1) summary
    cd10416
    Location:87188
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    156806238..156816853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002767.1XP_016858256.1  SH2 domain-containing protein 2A isoform X7

  2. XM_017002763.1XP_016858252.1  SH2 domain-containing protein 2A isoform X2

  3. XM_017002766.1XP_016858255.1  SH2 domain-containing protein 2A isoform X6

  4. XM_006711615.2XP_006711678.1  SH2 domain-containing protein 2A isoform X3

    Conserved Domains (1) summary
    cd10416
    Location:93194
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  5. XM_017002762.2XP_016858251.1  SH2 domain-containing protein 2A isoform X1

  6. XM_017002765.1XP_016858254.1  SH2 domain-containing protein 2A isoform X5

  7. XM_017002764.2XP_016858253.1  SH2 domain-containing protein 2A isoform X4

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