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SH2D2A SH2 domain containing 2A [ Homo sapiens (human) ]

Gene ID: 9047, updated on 23-Nov-2023

Summary

Official Symbol
SH2D2Aprovided by HGNC
Official Full Name
SH2 domain containing 2Aprovided by HGNC
Primary source
HGNC:HGNC:10821
See related
Ensembl:ENSG00000027869 MIM:604514; AllianceGenome:HGNC:10821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCAP; TSAD; VRAP; F2771
Summary
This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Expression
Broad expression in appendix (RPKM 5.2), lymph node (RPKM 3.5) and 17 other tissues See more
Orthologs
NEW
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Genomic context

See SH2D2A in Genome Data Viewer
Location:
1q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156806243..156816848, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155943096..155953700, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156776035..156786640, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717051-156717748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717749-156718446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156718447-156719143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156721068-156721842 Neighboring gene mitochondrial ribosomal protein L24 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156729657-156730190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156730191-156730723 Neighboring gene heparin binding growth factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156736100-156736726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156736727-156737352 Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene Sharpr-MPRA regulatory region 3718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156774267-156774768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156778787-156779288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156783176-156783722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1438 Neighboring gene neurotrophic receptor tyrosine kinase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156808560-156809060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156811133-156811814 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156811815-156812494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156814249-156814884 Neighboring gene Sharpr-MPRA regulatory region 5756 Neighboring gene insulin receptor related receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156830955-156831498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156836581-156837238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156844837-156845734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156862813-156863317 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:156865761-156866960 Neighboring gene platelet endothelial aggregation receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
SH2 domain-containing protein 2A
Names
SH2 domain protein 2A
T cell specific adapter protein TSAd
T lymphocyte specific adaptor protein
VEGF receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016849.1 RefSeqGene

    Range
    5001..15606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161441.2NP_001154913.1  SH2 domain-containing protein 2A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL158169, AY763099, BQ012931, DB128222
    Consensus CDS
    CCDS53381.1
    UniProtKB/TrEMBL
    Q5UBZ2
    Related
    ENSP00000376123.2, ENST00000392306.2
    Conserved Domains (1) summary
    cl15255
    Location:87198
    SH2; Src homology 2 (SH2) domain
  2. NM_001161442.2NP_001154914.1  SH2 domain-containing protein 2A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF051325, AL158169, DB128222
    Consensus CDS
    CCDS53380.1
    UniProtKB/TrEMBL
    Q5UBZ3
    Related
    ENSP00000357181.3, ENST00000368198.7
    Conserved Domains (1) summary
    cd10416
    Location:69170
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  3. NM_001161443.2NP_001154915.1  SH2 domain-containing protein 2A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, has multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AL158169, AY763098, BQ012931
    UniProtKB/TrEMBL
    Q5UBZ3
    Conserved Domains (1) summary
    cd10416
    Location:59160
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  4. NM_001161444.2NP_001154916.1  SH2 domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_001154916.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR, and coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AK222737, DB128222
    Consensus CDS
    CCDS1159.1
    UniProtKB/Swiss-Prot
    O43817, Q5UBZ1, Q5VZS4, Q5VZS5, Q9NP31, Q9UPA7
    UniProtKB/TrEMBL
    B2R9A4
    Conserved Domains (1) summary
    cd10416
    Location:87188
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  5. NM_003975.4NP_003966.2  SH2 domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_003966.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 5 encode the same isoform (2).
    Source sequence(s)
    AL158169, BC012107, DB128222
    Consensus CDS
    CCDS1159.1
    UniProtKB/Swiss-Prot
    O43817, Q5UBZ1, Q5VZS4, Q5VZS5, Q9NP31, Q9UPA7
    UniProtKB/TrEMBL
    B2R9A4
    Related
    ENSP00000357182.3, ENST00000368199.8
    Conserved Domains (1) summary
    cd10416
    Location:87188
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156806243..156816848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433655.1XP_047289611.1  SH2 domain-containing protein 2A isoform X7

    UniProtKB/TrEMBL
    Q5UBZ3
  2. XM_017002766.2XP_016858255.1  SH2 domain-containing protein 2A isoform X5

    UniProtKB/TrEMBL
    Q5UBZ3
  3. XM_017002765.2XP_016858254.1  SH2 domain-containing protein 2A isoform X4

    UniProtKB/TrEMBL
    Q5UBZ3
  4. XM_017002764.3XP_016858253.1  SH2 domain-containing protein 2A isoform X3

    UniProtKB/TrEMBL
    B2R9A4
  5. XM_006711615.3XP_006711678.1  SH2 domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    B2R9A4
    Conserved Domains (1) summary
    cd10416
    Location:93194
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  6. XM_017002762.3XP_016858251.1  SH2 domain-containing protein 2A isoform X1

    UniProtKB/TrEMBL
    Q5UBZ2
  7. XM_047433652.1XP_047289608.1  SH2 domain-containing protein 2A isoform X6

    UniProtKB/TrEMBL
    Q5UBZ2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155943096..155953700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339509.1XP_054195484.1  SH2 domain-containing protein 2A isoform X7

    UniProtKB/TrEMBL
    Q5UBZ3
  2. XM_054339507.1XP_054195482.1  SH2 domain-containing protein 2A isoform X5

    UniProtKB/TrEMBL
    Q5UBZ3
  3. XM_054339506.1XP_054195481.1  SH2 domain-containing protein 2A isoform X4

    UniProtKB/TrEMBL
    Q5UBZ3
  4. XM_054339505.1XP_054195480.1  SH2 domain-containing protein 2A isoform X3

    UniProtKB/TrEMBL
    B2R9A4
  5. XM_054339504.1XP_054195479.1  SH2 domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    B2R9A4
  6. XM_054339503.1XP_054195478.1  SH2 domain-containing protein 2A isoform X1

    UniProtKB/TrEMBL
    Q5UBZ2
  7. XM_054339508.1XP_054195483.1  SH2 domain-containing protein 2A isoform X6

    UniProtKB/TrEMBL
    Q5UBZ2