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Sh2d2a SH2 domain containing 2A [ Mus musculus (house mouse) ]

Gene ID: 27371, updated on 9-Sep-2018

Summary

Official Symbol
Sh2d2aprovided by MGI
Official Full Name
SH2 domain containing 2Aprovided by MGI
Primary source
MGI:MGI:1351596
See related
Ensembl:ENSMUSG00000028071 Vega:OTTMUSG00000051868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lad; Ribp; Tsad
Expression
Biased expression in thymus adult (RPKM 35.7), spleen adult (RPKM 8.0) and 1 other tissue See more
Orthologs

Genomic context

See Sh2d2a in Genome Data Viewer
Location:
3 F1; 3 38.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (87846755..87855722)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (87650677..87659644)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105244486 Neighboring gene predicted gene, 40086 Neighboring gene papillary renal cell carcinoma (translocation-associated) Neighboring gene hepatoma-derived growth factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
SH3/SH2 adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH2 domain-containing protein 2A
Names
Lck-associated adapter protein
Rlk/Itk-binding protein
SH2 domain protein 2A
T cell-specific adapter protein
p56Lck-associated adapter protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025571.2NP_001020742.1  SH2 domain-containing protein 2A isoform 2

    See identical proteins and their annotated locations for NP_001020742.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC161454, AK037489, BB154497
    Consensus CDS
    CCDS17455.1
    UniProtKB/TrEMBL
    Q5D0E4
    Related
    ENSMUSP00000029709.5, OTTMUSP00000069979, ENSMUST00000029709.6, OTTMUST00000130613
    Conserved Domains (1) summary
    cd10416
    Location:108209
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)
  2. NM_021309.3NP_067284.1  SH2 domain-containing protein 2A isoform 1

    See identical proteins and their annotated locations for NP_067284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161454, AK037489, BB154497
    Consensus CDS
    CCDS38476.1
    UniProtKB/Swiss-Prot
    Q9QXK9
    UniProtKB/TrEMBL
    Q5D0E4
    Related
    ENSMUSP00000103207.2, OTTMUSP00000069978, ENSMUST00000107581.8, OTTMUST00000130612
    Conserved Domains (1) summary
    cd10416
    Location:108209
    SH2_SH2D2A; Src homology 2 domain found in the SH2 domain containing protein 2A (SH2D2A)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    87846755..87855722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501556.3XP_006501619.1  SH2 domain-containing protein 2A isoform X4

    Conserved Domains (1) summary
    cl15255
    Location:108154
    SH2; Src homology 2 (SH2) domain
  2. XM_017319606.1XP_017175095.1  SH2 domain-containing protein 2A isoform X3

  3. XM_006501554.3XP_006501617.1  SH2 domain-containing protein 2A isoform X1

    Conserved Domains (1) summary
    cl15255
    Location:108225
    SH2; Src homology 2 (SH2) domain
  4. XM_006501555.3XP_006501618.1  SH2 domain-containing protein 2A isoform X2

    Conserved Domains (1) summary
    cl15255
    Location:108225
    SH2; Src homology 2 (SH2) domain
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