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ZNF622 zinc finger protein 622 [ Homo sapiens (human) ]

Gene ID: 90441, updated on 7-Jan-2024

Summary

Official Symbol
ZNF622provided by HGNC
Official Full Name
zinc finger protein 622provided by HGNC
Primary source
HGNC:HGNC:30958
See related
Ensembl:ENSG00000173545 MIM:608694; AllianceGenome:HGNC:30958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZPR9
Summary
Enables RNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 14.7), colon (RPKM 14.5) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF622 in Genome Data Viewer
Location:
5p15.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (16451519..16465800, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (16390866..16405145, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (16451628..16465909, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NACA pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16335723-16336270 Neighboring gene long intergenic non-protein coding RNA 2150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16436325-16436842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22421 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16467094-16467316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22423 Neighboring gene reticulophagy regulator 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16535515-16536016 Neighboring gene Sharpr-MPRA regulatory region 7449 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:16575232-16575796 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:16606665-16606881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15947 Neighboring gene RETREG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16711171-16711672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16718131-16718712 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:16721745-16722434 Neighboring gene myosin X Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:16741036-16741940 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16741941-16742846 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:16754668-16755308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16755309-16755949 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794335-16794862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16794863-16795390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16805998-16806498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:16806499-16806999 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:16809483-16809982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:16829693-16830613 Neighboring gene RNA, 5S ribosomal pseudogene 179

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2485, MGC17552

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables preribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cytoplasmic 60S subunit biogenesis factor ZNF622
Names
zinc finger-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033414.3NP_219482.1  cytoplasmic 60S subunit biogenesis factor ZNF622

    See identical proteins and their annotated locations for NP_219482.1

    Status: VALIDATED

    Source sequence(s)
    AC020980, BC008752
    Consensus CDS
    CCDS3886.1
    UniProtKB/Swiss-Prot
    Q969S3
    Related
    ENSP00000310042.2, ENST00000308683.3
    Conserved Domains (4) summary
    PTZ00448
    Location:649
    PTZ00448; hypothetical protein; Provisional
    sd00020
    Location:628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:6891
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    pfam12756
    Location:254353
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    16451519..16465800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    16390866..16405145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)