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SPAG9 sperm associated antigen 9 [ Homo sapiens (human) ]

Gene ID: 9043, updated on 4-Nov-2018

Summary

Official Symbol
SPAG9provided by HGNC
Official Full Name
sperm associated antigen 9provided by HGNC
Primary source
HGNC:HGNC:14524
See related
Ensembl:ENSG00000008294 MIM:605430; Vega:OTTHUMG00000162316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JLP; CT89; HLC4; HLC6; JIP4; PHET; PIG6; HLC-6; JIP-4
Summary
This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in brain (RPKM 29.0), testis (RPKM 27.0) and 25 other tissues See more
Orthologs

Genomic context

See SPAG9 in Genome Data Viewer
Location:
17q21.33
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (50962174..51120865, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49039535..49198226, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TOB1 antisense RNA 1 Neighboring gene uncharacterized LOC105371825 Neighboring gene transducer of ERBB2, 1 Neighboring gene NME1-NME2 readthrough Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • CDO in myogenesis, organism-specific biosystem (from REACTOME)
    CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Myogenesis, organism-specific biosystem (from REACTOME)
    Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13450, FLJ14006, FLJ26141, FLJ34602, KIAA0516, MGC14967, MGC74461, MGC117291

Gene Ontology Provided by GOA

Function Evidence Code Pubs
JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 4
Names
JNK interacting protein
JNK/SAPK-associated protein
Max-binding protein
c-Jun NH2-terminal kinase-associated leucine zipper protein
cancer/testis antigen 89
human lung cancer oncogene 6 protein
lung cancer oncogene 4
mitogen-activated protein kinase 8-interacting protein 4
proliferation-inducing gene 6
protein highly expressed in testis
sperm associated antigen 9 variant 5
sperm surface protein
sunday driver 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029710.1 RefSeqGene

    Range
    5001..163692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130527.2NP_001123999.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001123999.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC005920, AF327452, AY236487, DA631864
    Consensus CDS
    CCDS58578.1
    UniProtKB/Swiss-Prot
    O60271
    UniProtKB/TrEMBL
    Q5JB53
    Related
    ENSP00000426900.1, OTTHUMP00000221892, ENST00000505279.5, OTTHUMT00000368545
    Conserved Domains (2) summary
    pfam09744
    Location:25178
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:392447
    JIP_LZII; JNK-interacting protein leucine zipper II
  2. NM_001130528.2NP_001124000.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001124000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005920, AK091921, BC146755
    Consensus CDS
    CCDS45740.1
    UniProtKB/Swiss-Prot
    O60271
    Related
    ENSP00000262013.7, OTTHUMP00000221890, ENST00000262013.11, OTTHUMT00000368543
    Conserved Domains (2) summary
    pfam09744
    Location:25178
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:406461
    JIP_LZII; JNK-interacting protein leucine zipper II
  3. NM_001251971.1NP_001238900.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (4) has a distinct N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AC005920, AK295098, DC332810
    Consensus CDS
    CCDS58577.1
    UniProtKB/Swiss-Prot
    O60271
    Related
    ENSP00000423165.1, OTTHUMP00000221896, ENST00000510283.5, OTTHUMT00000368549
    Conserved Domains (1) summary
    pfam16471
    Location:249304
    JIP_LZII; JNK-interacting protein leucine zipper II
  4. NM_003971.5NP_003962.3  C-Jun-amino-terminal kinase-interacting protein 4 isoform 3

    See identical proteins and their annotated locations for NP_003962.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon in the coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC005920, AK091921, AY850123
    Consensus CDS
    CCDS11577.1
    UniProtKB/Swiss-Prot
    O60271
    Related
    ENSP00000349636.4, OTTHUMP00000221891, ENST00000357122.8, OTTHUMT00000368544
    Conserved Domains (2) summary
    pfam09744
    Location:25178
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:392447
    JIP_LZII; JNK-interacting protein leucine zipper II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    50962174..51120865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257768.2XP_005257825.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X1

    Conserved Domains (2) summary
    pfam09744
    Location:25178
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:406461
    JIP_LZII; JNK-interacting protein leucine zipper II
  2. XM_005257771.3XP_005257828.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X2

    See identical proteins and their annotated locations for XP_005257828.1

    Conserved Domains (2) summary
    pfam09744
    Location:25178
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:392447
    JIP_LZII; JNK-interacting protein leucine zipper II
  3. XM_017025285.2XP_016880774.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X6

  4. XM_005257774.4XP_005257831.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X5

    Conserved Domains (1) summary
    pfam16471
    Location:249304
    JIP_LZII; JNK-interacting protein leucine zipper II
  5. XM_017025283.2XP_016880772.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X3

  6. XM_017025284.2XP_016880773.1  C-Jun-amino-terminal kinase-interacting protein 4 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172345.1: Suppressed sequence

    Description
    NM_172345.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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