Format

Send to:

Choose Destination

MPZL1 myelin protein zero like 1 [ Homo sapiens (human) ]

Gene ID: 9019, updated on 4-Jul-2021

Summary

Official Symbol
MPZL1provided by HGNC
Official Full Name
myelin protein zero like 1provided by HGNC
Primary source
HGNC:HGNC:7226
See related
Ensembl:ENSG00000197965 MIM:604376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PZR; PZRa; PZRb; PZR1b; MPZL1b
Expression
Ubiquitous expression in gall bladder (RPKM 26.1), placenta (RPKM 23.6) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MPZL1 in Genome Data Viewer
Location:
1q24.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (167721982..167791919)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167691219..167761156)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Pro (anticodon CGG) 1-1 Neighboring gene tRNA-Pro (anticodon AGG) 2-1 Neighboring gene adenylate cyclase 10 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene DDB1 and CUL4 associated factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of MPZL1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21047

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
myelin protein zero-like protein 1
Names
immunoglobulin family transmembrane protein
protein zero related

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146191.2NP_001139663.1  myelin protein zero-like protein 1 isoform c precursor

    See identical proteins and their annotated locations for NP_001139663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK297112, AW292498, Z99943
    Consensus CDS
    CCDS53425.1
    UniProtKB/Swiss-Prot
    O95297
    Related
    ENSP00000375968.3, ENST00000392121.7
    Conserved Domains (1) summary
    cl11960
    Location:3986
    Ig; Immunoglobulin domain
  2. NM_003953.6NP_003944.1  myelin protein zero-like protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_003944.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AW292498, AY359019, DA725074, Z99943
    Consensus CDS
    CCDS1264.1
    UniProtKB/Swiss-Prot
    O95297
    UniProtKB/TrEMBL
    A8K5D4
    Related
    ENSP00000352513.2, ENST00000359523.7
    Conserved Domains (2) summary
    cd05715
    Location:39154
    Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
    smart00410
    Location:43154
    IG_like; Immunoglobulin like
  3. NM_024569.5NP_078845.3  myelin protein zero-like protein 1 isoform b precursor

    See identical proteins and their annotated locations for NP_078845.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF478447, AW292498, DA725074, Z99943
    Consensus CDS
    CCDS44273.1
    UniProtKB/Swiss-Prot
    O95297
    UniProtKB/TrEMBL
    A0A024R8Y3
    Related
    ENSP00000420455.1, ENST00000474859.5
    Conserved Domains (2) summary
    cd05715
    Location:39154
    Ig_P0-like; Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
    smart00410
    Location:43154
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    167721982..167791919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center