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TAF1B TATA-box binding protein associated factor, RNA polymerase I subunit B [ Homo sapiens (human) ]

Gene ID: 9014, updated on 13-Mar-2020

Summary

Official Symbol
TAF1Bprovided by HGNC
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I subunit Bprovided by HGNC
Primary source
HGNC:HGNC:11533
See related
Ensembl:ENSG00000115750 MIM:604904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SL1; RAF1B; RAFI63; TAFI63; MGC:9349
Summary
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in testis (RPKM 5.9), placenta (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See TAF1B in Genome Data Viewer
Location:
2p25.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (9843442..9934416)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9983571..10074545)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996549 Neighboring gene Sharpr-MPRA regulatory region 12215 Neighboring gene uncharacterized LOC105373421 Neighboring gene uncharacterized LOC105373422 Neighboring gene grainyhead like transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase I CORE element sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase I CORE element sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
TBP-class protein binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase I core factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase I core factor complex IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase transcription factor SL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit B
Names
RNA polymerase I-specific TBP-associated factor 63 kDa
SL1, 63kD subunit
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD
TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TATA box-binding protein-associated factor 1B
TATA-box binding protein associated factor, RNA polymerase I, B
TBP-associated factor 1B
transcription initiation factor SL1/TIF-IB subunit B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318976.1NP_001305905.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AA746267, AC010969, AK295402, AK308070, DA910748
    UniProtKB/Swiss-Prot
    Q53T94
  2. NM_001318977.1NP_001305906.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AA746267, AC010969, AK026521, AK308070, DA910748
  3. NM_005680.3NP_005671.3  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC010969
    Consensus CDS
    CCDS33143.1
    Related
    ENSP00000263663.4, ENST00000263663.10
    Conserved Domains (1) summary
    pfam11781
    Location:739
    zf-RRN7; Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    9843442..9934416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510411.1XP_011508713.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X2

  2. XM_024453209.1XP_024308977.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X3

  3. XM_011510410.2XP_011508712.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X1

    Conserved Domains (1) summary
    pfam11781
    Location:639
    RRN7; RNA polymerase I-specific transcription initiation factor Rrn7
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