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Taf1b TATA-box binding protein associated factor, RNA polymerase I, B [ Mus musculus (house mouse) ]

Gene ID: 21340, updated on 8-May-2024

Summary

Official Symbol
Taf1bprovided by MGI
Official Full Name
TATA-box binding protein associated factor, RNA polymerase I, Bprovided by MGI
Primary source
MGI:MGI:109577
See related
Ensembl:ENSMUSG00000059669 AllianceGenome:MGI:109577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p63; TAFI68; Tafi86; 4930408G01Rik; A230108M10Rik
Summary
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and nucleolar large rRNA transcription by RNA polymerase I. Predicted to act upstream of or within transcription by RNA polymerase I. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of RNA polymerase I core factor complex and RNA polymerase transcription factor SL1 complex. Is expressed in heart and limb. Orthologous to human TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 7.5), CNS E14 (RPKM 6.5) and 24 other tissues See more
Orthologs
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Genomic context

See Taf1b in Genome Data Viewer
Location:
12 A1.3; 12 8.49 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (24548580..24608570)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (24498581..24558571)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamic acid 14 (anticodon CTC) Neighboring gene STARR-seq mESC enhancer starr_31751 Neighboring gene actin related protein 2/3 complex, subunit 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31752 Neighboring gene STARR-positive B cell enhancer mm9_chr12:25256927-25257228 Neighboring gene grainyhead like transcription factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:25278331-25278514 Neighboring gene cytochrome c oxidase subunit VIIa polypeptide 2-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase I core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase I core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase I core factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase I core factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase I transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 
part_of RNA polymerase transcription factor SL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase transcription factor SL1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TATA box-binding protein-associated factor RNA polymerase I subunit B
Names
RNA polymerase I-specific TBP-associated factor 68 kDa
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
TATA box-binding protein-associated factor 1B
TBP-associated factor 1B
TBP-associated factor RNA polymerase I 68
transcription factor TAFI68
transcription initiation factor SL1/TIF-IB subunit B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020614.2NP_065639.2  TATA box-binding protein-associated factor RNA polymerase I subunit B

    See identical proteins and their annotated locations for NP_065639.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC125067, AK131963, CK619940
    Consensus CDS
    CCDS36419.1
    UniProtKB/Swiss-Prot
    E9QJY7, P97358, Q08AT7, Q3V292, Q6NSS9
    Related
    ENSMUSP00000075339.8, ENSMUST00000075954.9
    Conserved Domains (1) summary
    pfam11781
    Location:1039
    RRN7; RNA polymerase I-specific transcription initiation factor Rrn7

RNA

  1. NR_028341.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC125067, BC086643, CJ068630, CK619940, CN721617
    Related
    ENSMUST00000221372.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    24548580..24608570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515051.2XP_006515114.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X1