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F2RL3 F2R like thrombin or trypsin receptor 3 [ Homo sapiens (human) ]

Gene ID: 9002, updated on 4-Jun-2020

Summary

Official Symbol
F2RL3provided by HGNC
Official Full Name
F2R like thrombin or trypsin receptor 3provided by HGNC
Primary source
HGNC:HGNC:3540
See related
Ensembl:ENSG00000127533 MIM:602779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR4
Summary
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
Expression
Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues See more
Orthologs

Genomic context

See F2RL3 in Genome Data Viewer
Location:
19p13.11
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (16888999..16892606)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (16999826..17002830)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene SIN3 transcription regulator family member B Neighboring gene C3 and PZP like alpha-2-macroglobulin domain containing 8 Neighboring gene RNA, 7SL, cytoplasmic 835, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 823, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
proteinase-activated receptor 4
Names
F2R like thrombin/trypsin receptor 3
PAR-4
coagulation factor II (thrombin) receptor-like 3
protease-activated receptor-4
thrombin receptor-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032894.1 RefSeqGene

    Range
    4985..8592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003950.4NP_003941.2  proteinase-activated receptor 4 preproprotein

    See identical proteins and their annotated locations for NP_003941.2

    Status: REVIEWED

    Source sequence(s)
    AC008737, AF055917, BP281855, BQ269855
    Consensus CDS
    CCDS12350.1
    UniProtKB/Swiss-Prot
    Q96RI0
    Related
    ENSP00000248076.2, ENST00000248076.4
    Conserved Domains (1) summary
    pfam00001
    Location:131340
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    16888999..16892606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260139.2XP_005260196.1  proteinase-activated receptor 4 isoform X1

    Conserved Domains (1) summary
    pfam00001
    Location:19228
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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