Format

Send to:

Choose Destination

F2rl3 coagulation factor II (thrombin) receptor-like 3 [ Mus musculus (house mouse) ]

Gene ID: 14065, updated on 18-Sep-2018

Summary

Official Symbol
F2rl3provided by MGI
Official Full Name
coagulation factor II (thrombin) receptor-like 3provided by MGI
Primary source
MGI:MGI:1298207
See related
Ensembl:ENSMUSG00000050147 Vega:OTTMUSG00000062066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAR4
Summary
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Mice lacking a functional copy of this gene exhibit impaired platelet activation and prolonged bleeding times. [provided by RefSeq, Sep 2016]
Expression
Broad expression in spleen adult (RPKM 9.1), thymus adult (RPKM 4.3) and 20 other tissues See more
Orthologs

Genomic context

See F2rl3 in Genome Data Viewer
Location:
8 35.08 cM; 8 B3.3
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (72760883..72763898)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (75285779..75287784)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene NACHT and WD repeat domain containing 1 Neighboring gene transcriptional regulator, SIN3B (yeast) Neighboring gene predicted gene, 39198 Neighboring gene LARGE xylosyl- and glucuronyltransferase 1 Neighboring gene microRNA 28b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thrombin-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
hemostasis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
thrombin-activated receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteinase-activated receptor 4
Names
PAR-4
coagulation factor II receptor-like 3
thrombin receptor-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007975.4NP_032001.2  proteinase-activated receptor 4 preproprotein

    See identical proteins and their annotated locations for NP_032001.2

    Status: REVIEWED

    Source sequence(s)
    AI413964, AK036427, BY344718
    Consensus CDS
    CCDS22419.1
    UniProtKB/Swiss-Prot
    O88634
    Related
    ENSMUSP00000054426.8, OTTMUSP00000078593, ENSMUST00000058099.8, OTTMUST00000151554
    Conserved Domains (1) summary
    pfam00001
    Location:107352
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    72760883..72763898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530660.3XP_006530723.1  proteinase-activated receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006530723.1

    UniProtKB/TrEMBL
    Q0VDX1
    Conserved Domains (1) summary
    pfam00001
    Location:16225
    7tm_1; 7 transmembrane receptor (rhodopsin family)
Support Center